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TranscriptomicsTranscription profiling of human TLR2/1 stimulated human monocytes with the Mycobacterium tuberculosis derived 19kDa lipopeptide reveals Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response
In innate immune responses, activation of Toll-like receptors (TLRs) triggers direct antimicrobial activity against intracellular bacteria, which in murine, but not human, monocytes and macrophages is mediated principally by nitric oxide. We report here that TLR activation of human macrophages up-re...
ORGANISM(S): Homo sapiens 
2008-06-17 | E-GEOD-8921 | biostudies-arrayexpress
UnknownDAVID Bioinformatics Resources: expanded annotation database and novel algorithms to better extract biology from large gene lists.
Not available
S-EPMC1933169 | biostudies-literature
UnknownDAVID Knowledgebase: a gene-centered database integrating heterogeneous gene annotation resources to facilitate high-throughput gene functional analysis.
Not available
S-EPMC2186358 | biostudies-literature
MetabolomicsDeficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease
Non-alcoholic fatty liver is the most common liver disease worldwide. Here, we show that the mitochondrial protein mitofusin 2 (Mfn2) protects against liver disease. Reduced Mfn2 expression was detected in liver biopsies from patients with non-alcoholic steatohepatitis (NASH). Moreover, reduced Mfn2...
2018-01-25 | MTBLS600 | MetaboLights
ProteomicsTotal proteome analysis of WT vs TRAP1 KO in HCT-116 and HEK-293T cells grown on different carbon sources.
The molecular chaperone TRAP1, the mitochondrial isoform of cytosolic HSP90, remains poorly understood with respect to its pivotal role in the regulation of mitochondrial metabolism. To characterize the impact of TRAP1 in maintaining the cellular proteome under different energy sources we carried ou...
ORGANISM(S): Homo sapiens (Human) 
2020-01-16 | PXD015828 | Pride
Oxidative phosphorylation Trap1 Mitochondrion Hsp90 Molecular chaperone 
UnknownVersatile use of microliths as a technological advantage in the miniaturization of Late Pleistocene toolkits: The case study of Neve David, Israel.
Not available
S-EPMC7269238 | biostudies-literature
ProteomicsProteomic Analysis of rattus norvegicus colonic mucosa following acupuncture treatment for irritable bowel syndrome with diarrhea by label-free LC–MS/MS
To investigate the molecular pathological mechanisms of irritable bowel syndrome with diarrhea (IBS-D) and elucidate the effects of acupuncture on IBS-D colonic mucosa protein abundance in rats, a label-free high-throughput liquid chromatography-tandem mass spectrometry (LC-MS)-based proteomics anal...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-10-14 | PXD025558 | Pride
Lc-msms Colonic mucosa Rat Acupuncture 
UnknownD-2-Hydroxyglutarate Is Necessary and Sufficient for Isocitrate Dehydrogenase 1 Mutant-Induced MIR148A Promoter Methylation.
Not available
S-EPMC5984679 | biostudies-literature
UnknownDetecting Germline PTEN Mutations Among At-Risk Patients With Cancer: An Age- and Sex-Specific Cost-Effectiveness Analysis.
Not available
S-EPMC4525048 | biostudies-literature
TranscriptomicsPilot KOMP knockout mouse strains
This is a test case of D. West's RNA-seq from KOMP2 mutant strains
ORGANISM(S): Mus musculus 
2015-12-28 | E-MTAB-3662 | biostudies-arrayexpress
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