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MetabolomicsPKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis
Metabolic reprogramming is a hallmark of cancer. Herein we discover that the key glycolytic enzyme pyruvate kinase M2 isoform (PKM2), but not the related isoform PKM1, is methylated by co-activator-associated arginine methyltransferase 1 (CARM1). PKM2 methylation reversibly shifts the balance of met...
2021-07-30 | MTBLS533 | MetaboLights
ProteomicsPKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis
Global proteome comparison between breast cancer MCF7 parental cell and PKM2 KO cell
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD007671 | Pride
Lc-ms Breast cancer 
ProteomicsSurfactant and chaotropic agent assisted sequential extraction/on pellet digestion (SCAD) for enhanced proteomics
As a popular sample preparation approach, Filter-aided sample preparation (FASP) has been widely used in proteomic analysis. However, several limitations have been noted, including sample loss during filtration, repetitive centrifugation steps, and the possibility of breakage of filtration membrane....
ORGANISM(S): Homo sapiens (Human) 
2018-10-19 | PXD008967 | Pride
Urea Protein digestion Protein detection Protein extraction Peptide sequencing Lfq Scad Ibaq Fasp 
ProteomicsLysine-targeting, covalent inhibitors of bromodomain BD1 of BET proteins in live cells and animals
We report herein a set of activity-based probes (ABPs; P3-P7) based on various lysine-reactive covalent warheads capable of global profiling of ligandable lysine within BRDs in live cells and animals. Chemoproteomic experiments with P7 by utilizing 2-ethynylbenzaldehyde (EBA) identified 18 endogenou...
ORGANISM(S): Homo Sapiens Mus Musculus 
2025-04-10 | PXD058513 |
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