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ProteomicsOsteopontin Regulation of MerTK+ Macrophages Promotes Crohn’s Disease Intestinal Fibrosis
The pathogenesis of intestinal fibrosis in Crohn’s disease (CD) remains unclear. Mer receptor tyrosine kinase (MerTK) is an immunosuppressive protein specifically expressed in macrophages. Osteopontin (OPN), also known as secreted phosphoprotein 1, contributes to inflammation and wound repair. This ...
ORGANISM(S): Mus Musculus 
PXD052743 |
ProteomicsProteome profiling of intestine under DMXAA stimuli
Proteome profiling dataset of intestine under DMXAA stimuli.
ORGANISM(S): Mus Musculus 
2022-06-16 | PXD034614 |
ProteomicsEffects of 3D printing HUVEC(vefg165+) -laden hydrogel on diabetic wound healing
By constructing specific lentiviral vector, vefg165 protein was overexpressed in HUVEC cells. Using light-curing bioprinting, HUVEC(vefg165+)-loaded hydrogels and HUVEC(vector)-loaded hydrogels were prepared, and were used to treat rat diabetic wounds. The regenerated skin tissues (five samples for ...
ORGANISM(S): Rattus Norvegicus 
2022-08-12 | PXD036045 |
ProteomicsMacrophage MERTK restrains GRAMD1A‑driven mitochondrial cholesterol trafficking to limit colitis
Failed clearance of apoptotic cells drives pathogen persistence, tissue damage, and damage associated molecular patterns accumulation, fueling immune remodeling. Despite its pathophysiological significance, the precise immunometabolic reprogramming underlying impaired phagocytic signaling in macroph...
ORGANISM(S): Homo Sapiens 
PXD069433 |
Metabolomics4-Octyl itaconate as a metabolite derivative inhibits inflammation via alkylation of STING

The Krebs cycle-derived metabolite itaconate, whose production is catalyzed by immune response gene 1 (IRG1), has excellent potential to link immunity and metabolism in activated macrophages through alkylation or competitive inhibition of target proteins. In support of this, our previous study de...

2023-01-15 | MTBLS5877 | MetaboLights
ProteomicsAlcoholic Liver Disease Human Serum Proteomics
Alcoholic liver disease LC-MS/MS quantitative proteomics with top14 abundant protein depletion
ORGANISM(S): Homo Sapiens 
2022-09-22 | PXD036941 |
ProteomicsChloroplast proteomics of wheat under drought
Perturbance of chloroplast proteins is a major cause of photosynthesis inhibition under drought stress. Exogenous application of 5-aminolevulinic acid (ALA) mitigates the damages caused by drought stress protecting plant growth and development, but the regulatory mechanism behind was still obscure. ...
ORGANISM(S): Triticum Aestivum 
2018-12-10 | PXD017528 |
ProteomicsMulti-omic analysis reveals a CAF-stemness-governed classification in HCC liver transplant recipients
In patients with hepatocellular carcinoma (HCC) meeting the Milan criteria, liver transplantation (LT) is an effective therapy. This study aims to define the survival-related molecular biological features helping precisely identifying the patients with HCC beyond the Milan criteria who have acceptab...
ORGANISM(S): Homo Sapiens 
2025-02-24 | PXD061119 |
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