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ProteomicsProteomics in biomanufacturing control: Protein dynamics of CHO-K1 cells and conditioned media during apoptosis and necrosis
Cell viability has a critical impact on product quantity and quality during the biomanufacturing of therapeutic proteins. An advanced understanding of changes in the cellular and conditioned media proteomes upon cell stress and death is therefore needed for improved bioprocess control. Here, a high ...
ORGANISM(S): Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2018-02-27 | PXD008297 | Pride
Proteomics Cho Keywords: biomanufacturing Necrosis Apoptosis 2d-lc-mse 
Other,MultiomicsChevrette et al 2019 Insect-associated Streptomyces
Paper title: The antimicrobial potential of Streptomyces from insect microbiomes. Author list: Chevrette MG, Carlson CM, Ortega HE, Thomas C, Ananiev GE, Barns KJ, Book AJ, Cagnazzo J, Carlos C, Flanigan W, Grubbs KJ, Horn HA, Hoffmann FM, Klassen JL, Knack JJ, Lewin GR, McDonald BR, Muller L, Melo ...
ORGANISM(S): Pseudonocardia Kitasatospora Streptomyces Gordonia <actinomycete> 
2019-12-18 | MSV000084723 | MassIVE
MetabolomicsComparison of lipidome profiles of Caenorhabditis elegans—results from an inter-laboratory ring trial

Introduction

Lipidomic profiling allows 100s if not 1000s of lipids in a sample to be detected and quantified. Modern lipidomics techniques are ultra-sensitive assays that enable the discovery of novel biomarkers in a variety of fields and provide new insight in mechanistic investigations. D...
2022-02-21 | MTBLS2016 | MetaboLights
MetabolomicsAntibacterial Monoclonal Antibodies Do Not Disrupt the Intestinal Microbiome or Its Function
Antibiotics revolutionized medicine, however, it is now clear that broad-spectrum antibiotics alter the composition and function of the host’s microbiome. The microbiome plays a key role in human health and its perturbation is increasingly recognized as contributing to many human diseases. Wide spre...
2021-01-11 | MTBLS1257 | MetaboLights
ProteomicsInherited C-terminal TREX1 variants disrupt homology-directed repair to cause senescence and DNA damage phenotypes in Drosophila, mice, and humans
Age-related microangiopathy, also known as small vessel disease (SVD), causes damage to the liver, brain, kidney and retina. Based on the DNA damage theory of aging, we reasoned that genomic instability may underlie an SVD caused by dominant C-terminal variants in TREX1, the most abundant 3’-5’ DNA ...
ORGANISM(S): Homo sapiens (Human) 
2024-05-30 | PXD051905 | Pride
Brca1 Retinal vasculopathy with cerebral leukoencephalopathy Cerebroretinal vasculopathy Rvcl-s Rvcl Trex1 Interferon Inflamm-aging Herns Crv Dementia Dna damage response Small vessel disease Vasculopathy 
UnknownRisk for non-home discharge following surgery for ischemic mitral valve disease.
Not available
S-EPMC7874266 | biostudies-literature
UnknownRetrospective evaluation of whole exome and genome mutation calls in 746 cancer samples.
Not available
S-EPMC7505971 | biostudies-literature
UnknownEffect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study.
Not available
S-EPMC8492020 | biostudies-literature
UnknownA prognostic model for use before elective surgery to estimate the risk of postoperative pulmonary complications (GSU-Pulmonary Score): a development and validation study in three international cohorts.
Not available
S-EPMC12056793 | biostudies-literature
UnknownSARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.
Not available
S-EPMC7995808 | biostudies-literature
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