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MetabolomicsTEX44 CPT1B Axis Regulates Mitochondrial Sheath Assembly and Fatty Acid Oxidation in Sperm

Mitochondrial fatty acid β-oxidation (FAO) is essential for energy production and cellular homeostasis, yet its specific role in sperm function has remained unclear. Through whole-exome sequencing of 673800 patients with asthenozoospermia, we identified biallelic TEX44 variants in six individuals...

2025-07-14 | MTBLS12402 | MetaboLights
TranscriptomicsRNA-seq from oocytes and zygotes of pabpn1l ko and wt female mice during different stages
PABPN1L participates in the process of post-transcriptional regulation and degradation of maternal mRNA.So,we collect samples of each period from pabpn1l ko and wt female mice during different stages.Then, RNA was extracted and detected.Reverse transcription was performed on the samples that met the...
ORGANISM(S): Mus musculus 
2021-03-19 | E-MTAB-10199 | biostudies-arrayexpress
MetabolomicsTEX44 CPT1B Axis Regulates Mitochondrial Sheath Assembly and Fatty Acid Oxidation in Sperm
Mitochondrial fatty acid β-oxidation (FAO) is essential for energy production and cellular homeostasis, yet its specific role in sperm function has remained unclear. Through whole-exome sequencing of 673 patients with asthenozoospermia, we identified biallelic TEX44 variants in six individuals, all ...
2025-07-14 | MTBLS12397 | MetaboLights
TranscriptomicsPnldc1 Total RNA-seq of P18 Testis
PIWI-interacting RNAs(piRNAs) are required for transposon repression, de novo DNA methylation, epigenetic and post-transcriptional regulation of gene expression in the germline. A mist of piRNA biogenesis is the identification of the 3’-5’ exnuclease that trimms the 3’ end of piRNA intermediates to ...
ORGANISM(S): Mus musculus 
2021-02-23 | E-MTAB-8335 | biostudies-arrayexpress
TranscriptomicsRNA-seq of oocytes and zygotes from pabpn1l ko and wt female mice
PABPN1L participates in the process of post-transcriptional regulation and degradation of maternal mRNA.We collect samples of each period from pabpn1l ko and wt female mice during different stages. Each group contained a total of 30 oocytes or zygotes. In the initial step, we spiked 2 × 106 mRNA-EGF...
ORGANISM(S): Mus musculus 
2021-03-26 | E-MTAB-10233 | biostudies-arrayexpress
ProteomicsIdentification of the CFAP65 interactome from mouse testis
Cfap65 was immunoprecipitated from mouse testis to identify the interactome of this protein for further functional studies.
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD055389 | Pride
Mouse Cfap65 Ip-ms Testis 
ProteomicsMouse Testis IP-MS Analysis of TEX44 Interacting Proteins
Through whole-exome sequencing of 800 patients with asthenozoospermia, we identified biallelic TEX44 variants in six individuals, all of whom exhibited defective mitochondrial sheath assembly and impaired sperm motility. Using Tex44 knockout mice, we demonstrated that TEX44 interacts with carnitine ...
ORGANISM(S): Mus Musculus 
2025-02-20 | PXD060989 |
MetabolomicsThe trans-omics landscape of COVID-19
The outbreak of coronavirus disease 2019 (COVID-19) is a global health emergency. Various omics results have been reported for COVID-19, but the molecular hallmarks of COVID-19, especially in those patients without comorbidities, have not been fully investigated. Here we collect blood samples from 2...
2021-10-06 | MTBLS2542 | MetaboLights
ProteomicsIdentification of the Key Protein Associated with Different Hair Types in Sheep and Goat
Animal-derived fiber has the characteristics of being light, soft, strong, elastic and a good thermal insulator and it is widely used in many industries and traditional products, so it plays an important role in the economy of some countries. Variations among phenotypes of wool fibers, among species...
ORGANISM(S): Ovis Aries Capra Hircus 
2022-09-09 | PXD036685 |
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