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ProteomicsCN-CHPP 2015 Testis Project - Tissue-Based Proteogenomics Reveals that Human Testis Endows Plentiful Missing Proteins
The testis tissue-based trans-omics was a feasible approach to find more missing proteins (MPs) because it was reported higher gene expression found in testis tissues. Three testis tissues and two protein separation strategies were selected to quantitatively evaluate gene expression abundance at the...
ORGANISM(S): Homo sapiens (Human) 
2015-11-03 | PXD002179 | Pride
Transcriptome Testis Chromosome-centric human proteome project Proteome Missing proteins 
ProteomicsTemperature-dependent Proteome Study of Thermoanaerobacter tengcongensis
Comprehensive and quantitative information of the thermophile proteome is an important source for understanding of the survival mechanism under high growth temperature. Thermoanaerobacter tengcongensis (T. tengcongensis), a typical anaerobic thermophilic eubacterium, was selected to quantitatively e...
ORGANISM(S): Thermoanaerobacter tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Caldanaerobacter subterraneus subsp. tengcongensis) 
2013-08-13 | PXD000264 | Pride
Ms/ms Tte Itraq 
MetabolomicsLipidomics profiling reveals the role of glycerophospholipid metabolism in psoriasis
Psoriasis is a common and chronic inflammatory skin disease complicated by genetic-environmental interactions. Although genomic, transcriptomic and proteomic analyses have been performed to investigate the pathogenesis of psoriasis, the role of metabolites in psoriasis, particularly of lipids, remai...
2017-08-22 | MTBLS408 | MetaboLights
UnknownA Combinational Strategy upon RNA Sequencing and Peptidomics Unravels a Set of Novel Toxin Peptides in Scorpion Mesobuthus martensii.
Not available
S-EPMC5086646 | biostudies-literature
ProteomicsPhosphoproteomics reveals that cinobufotalin promotes intrahepatic cholangiocarcinoma cell apoptosis by activating the ATM/CHK2/p53 signaling pathway
In this study, we found that CB inhibited ICC cell proliferation and promoted cell apoptosis. By using phosphoproteomics, we found significant changes in the proteome and phosphorylome associated with DNA damage and apoptosis in response to CB treatment. Further investigations demonstrated that CB i...
ORGANISM(S): Homo Sapiens 
2022-06-20 | PXD034717 |
TranscriptomicsLigand-Dependent Enhancer Activation Regulated by Topoisomerase-I Activity
The discovery that enhancers are regulated transcription units, encoding eRNAs, has raised new questions about the mechanisms of their activation. Here, we report an unexpected molecular mechanism that underlies ligand-dependent enhancer activation, based on DNA nicking to relieve torsional stress f...
ORGANISM(S): Homo sapiens 
2015-01-22 | E-GEOD-63202 | biostudies-arrayexpress
ProteomicsSynthetic yeast genome project
The experiment aimed to study the proteome variation in a yeast strain (YS031), which chromosome II was artificially synthezied, compared with the wild type strain (BY4741). Proteins were extracted from the yeast cells and digested with trypsin. The peptides were label with iTRAQ, separated with 2D ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2018-10-27 | PXD003435 | Pride
Saccharomyces cerevisiae Itraq Lc-ms/ms 
ProteomicsProteomic sequencing of Giardia duodenalis-secreted extracellular vesicles
The study involved the proteomic sequencing of extracellular vesicles secreted by Giardia duodenalis, statistical analysis of detected proteins, and GO analysis and enrichment KEGG analysis of proteins
ORGANISM(S): Giardia intestinalis (Giardia lamblia) 
2025-05-07 | PXD054439 | Pride
Giardia duodenalis  extracellular vesicles  lc-msms 
ProteomicsIdentification of DDR1-interacting proteins by IP-MS screening
To investigate and identify the potential DUBs that stabilize and interact with DDR1, we performed immunoprecipitation of endogenous DDR1 with anti-DDR1 antibody (specific IP) or anti-IgG antibody (negative control) in A549 cells followed by mass spectrometry analysis.
ORGANISM(S): Homo sapiens (Human) 
2025-09-08 | PXD065332 | Pride
Ddr1 Ip-ms Co-immunoprecipitated proteins 
TranscriptomicsEnhancer-bound LDB1 Regulates a Corticotrope Promoter Pausing Repression Program [GRO-seq]
Substantial evidence supports the hypothesis that enhancers are critical regulators of cell type determination, orchestrating both positive and negative transcriptional programs; however, the basic mechanisms by which enhancers orchestrate interactions with cognate promoters during activation and re...
ORGANISM(S): Mus musculus 
2015-02-03 | E-GEOD-64515 | biostudies-arrayexpress
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