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UnknownOptimization design and experiment of key components of mountain pendulum-lever cam type hole seeders based on DEM-MBD coupling simulation.
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S-EPMC11908703 | biostudies-literature
TranscriptomicsLoss of Olfactomedin 4 Leads to Neoplastic Progression in the Prostate
Purpose: To explore the mechanisms underlying increased tumorigenesis of Olfm4-deficient murine prostate. Experiment design: Comparison of gene expression between Olfm4-knockout and wild-type mice at 3 months of age in the prostate tissue. Experimental procedures: Total RNA was purified from whole p...
ORGANISM(S): Mus musculus 
2016-07-06 | E-GEOD-39989 | biostudies-arrayexpress
ProteomicsIdentifying interaction proteins of METTL3 and METTL14 using APEX2-based labeling and mass spectroscopy
During translation, protein quality control systems play an active role in ensuring the proper folding and assembly of proteins. To investigate the auxiliary factors that facilitate the folding and assembly of METTL3-METTL14, we employed proximity labeling technology using the split APEX2 system
ORGANISM(S): Homo Sapiens 
2025-12-05 | PXD071685 |
ProteomicsProbing the Role of O-GlcNAcylation in Modulating Protein-DNA Interactions: Insights from a Proteomic Transcription Factor Response Element-Based Pulldown Screening Approach
O-linked β-N-acetylglucosamine (O-GlcNAc), a critical post-translational modification (PTM) predominantly found in the nucleus, plays a substantial role in regulating gene expression by modulating transcription factors (TFs) activity. Herein, by utilizing a pulldown screening approach termed as tand...
ORGANISM(S): Homo Sapiens 
2024-10-24 | PXD057128 |
ProteomicsChromatin bound O-GlcNAc proteins related to stress response and transcriptional regulation.
O-GlcNAcylation performs a critical role in regulating stress response program and cellular homeostasis. However, systematic studies of O-GlcNAc regulated genotoxic stress-responsive transcriptional reprograming have been limited. The GalNAz metabolic labeled global chromatin-associated proteins wer...
ORGANISM(S): Homo Sapiens 
2020-08-30 | PXD016713 |
ProteomicsFOXA1 O-GlcNAcylation-mediated transcriptional switch governs metastasis capacity in breast cancer
The forkhead protein FOXA1 has been found to play a critical role in orchestrating hormonal-signaling network and to function as a pioneer factor to regulate breast-specific gene expression,However, whether interplay between O-GlcNAcylation and FOXA1 affects the genome-wide transcriptional activity ...
ORGANISM(S): Homo Sapiens 
2022-12-21 | PXD039019 |
ProteomicsO-GlcNAcylation elevates topoisomerase IIα catalytic activity: a role in the chemotherapy resistance of breast cancer
DNA topoisomerase IIα (TOP2A) plays a vital role in replication and cell division by catalytically altering DNA topology. It is a prominent target for anticancer drugs. However, it is currently unknown whether TOP2A is O-GlcNAc-modified, and the mechanism by which interplay between TOP2A and O-GlcNA...
ORGANISM(S): Homo Sapiens 
2023-03-31 | PXD041284 |
ProteomicsChromatin-associated OGT promotes hepatocellular carcinoma malignancy via activating ZNF263
OGT, the only facilitator which attaches the monosaccharide to many oncogenic factors or tumor suppressors, has been suggested to play an influential role in tumorigenesis and metastasis of HCC. OGT interactome analyses indicates that disordered OGT may serve as a hub protein to activate the buildin...
ORGANISM(S): Homo Sapiens 
2023-01-12 | PXD039365 |
ProteomicsO-mannosylated proteins secreted by BCG
we conducted a ConA lectin-affinity chromatography and mass spectra analysis to identify O-mannosylated proteins in BCG culture filtration.
ORGANISM(S): Mycobacterium Bovis Bcg Mycobacterium Bovis Bcg Str. China Mycobacterium Bovis Bcg Str. Glaxo Mycobacterium Bovis Bcg Str. Moreau Mycobacterium Bovis Bcg Str. Phipps Mycobacterium Bovis Bcg Str. Pasteur 1173p2 Mycobacterium Bovis Bcg Str. Sweden Mycobacterium Bovis Bcg Str. Tokyo 172 Mycobacterium Bovis Bcg Str. Frappier Mycobacterium Bovis Bcg Str. Korea 1168p 
2020-02-18 | PXD017576 |
ProteomicsChemically Engineered Antibodies for Autophagy-based Receptor Degradation.
Quantitative proteomic analysis raw data for the manuscript entitled “Chemically Engineered Antibodies for Autophagy-based Receptor Degradation”.
ORGANISM(S): Homo Sapiens 
2024-10-12 | PXD056766 |
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