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MetabolomicsMirabegron displays anticancer effects by globally browning adipose tissues

Metabolic reprogramming in malignant cells is a hallmark of cancer that relies on augmented glycolytic metabolism to support their growth, invasion and metastasis. However, the impact of global adipose metabolism on tumor growth and the drug development by targeting adipose metabolism remain larg...

2023-11-08 | MTBLS8682 | MetaboLights
ProteomicsMass spectrometry (MS) datasets of PURPL RNA pulldown samples in A375 cells
We performed PURPL RNA pulldown followed by MS analysis to identify purpl-interacting proteins in A375 cells.With high performance liquid chromatography-mass spectrometry (HPLC-MS), the binding protein of PURPL from RNA pull down was detected by removing non-specific protein which were binding with ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD028863 | Pride
Human a375 cells lc-ms 
ProteomicsHPLC-MS datasets of LINP1 RNA pulldown samples in A431 cells
We performed LINP1 RNA pulldown followed by HPLC-MS analysis to identify LINP1-interacting proteins in A431 cells. With high performance liquid chromatography-mass spectrometry (HPLC-MS), the binding protein of LINP1 from RNA pull down was detected by removing non-specific protein which were binding...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD032027 | Pride
Human a431 cells hplc-ms 
ProteomicsColistin resistance in Acinetobacter baumannii MDR-ZJ06 revealed by a multiomics approach
To explore how multiple drug-resistant A. baumannii response to colistin resistance, we compared the genomic, transcriptional and proteomic profile of A. baumannii MDR-ZJ06 to that of induced colistin resistant strain ZJ06-200P5-1.
ORGANISM(S): Acinetobacter baumannii 
2017-03-15 | PXD005265 | Pride
Colistin  acinetobacter baumannii 
ProteomicsProteome of extracellular vesicles derived from breast cancer cells
MDA-MB-231 cells were irradiated with 10 Gy X-rays and the medium was harvest for extracellular vesicles isolation 24 hours post-irradiation. Proteins carrying by EVs of irradiated and control cells were then analysed by LC-MS.
ORGANISM(S): Homo Sapiens 
2024-04-22 | PXD051650 |
ProteomicsAffinity purification of TRMT6/61A protein complexes
In order to identify the molecular mechanism leading to the increase of TRMT6/61A complex in aged HSCs, we purified proteins interacting with TRMT6 and TRMT61A via affinity purification. HEK293T cells stably expressing SFB-tagged TRMT6 or SFB-TRMT61A were lysed in NETN buffer (20 mM Tris-HCl [pH 8.0...
ORGANISM(S): Homo Sapiens 
2023-11-30 | PXD047430 |
ProteomicsPrognostic Biomarkers of Thymoma with Myasthenia Gravis Based on Serum Proteomics
Thymoma is often accompanied by myasthenia gravis (MG), and the resection of thymoma improves myasthenic symptoms in patients with thymoma and MG (TMG), but some patients still have no relief. Through proteomic analysis, we examined preoperative serum samples from patients with TMG to identify key p...
ORGANISM(S): Homo Sapiens 
2025-01-20 | PXD059952 |
ProteomicsIntegrin and hyperuricemia-related kidney fibrosis
We try to investigate the mechanism of kidney fibrosis from data-driven way using multi-omic data, to explore hub gene and key molecules of key interaction network.
ORGANISM(S): Mus Musculus 
2024-03-28 | PXD051046 |
TranscriptomicsMyeloid malignancies with chromosome 5q deletions acquire a dependency on an intrachromosomal NF-M-NM-:B gene network
Chromosome 5q deletions (del(5q)) are common in high-risk (HR) Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML); however, the gene regulatory networks that sustain these aggressive diseases are unknown. Reduced miR-146a expression in del(5q) HR-MDS/AML and miR-146a-/- hematopoietic st...
ORGANISM(S): Homo sapiens 
2014-08-23 | E-GEOD-60649 | biostudies-arrayexpress
ProteomicsGIST proteome dataset(Proteomic Maps of Human Gastrointestinal Stromal Tumor Subgroups)
Gastrointestinal stromal tumor (GIST) is a common sarcoma of gastrointestinal tract (GIT) with high metastatic and recurrence rates, but the proteomic features are still less understood. Here we performed systematic quantitative proteome profiling of GIST from 13 patients classified into very low/lo...
ORGANISM(S): Homo Sapiens 
2019-01-29 | PXD011299 |
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