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MetabolomicsA metabolome atlas of mouse brain on the global metabolic signature dynamics following short-term fasting
Calorie restriction (CR) or a fasting regimen is considered one of the most potent non-pharmacological interventions to prevent chronic metabolic disorders, ameliorate autoimmune diseases, and attenuate aging. Despite efforts, the mechanisms by which CR improves health, particularly brain health, ar...
2025-07-31 | MTBLS8006 | MetaboLights
GenomicsGenome-wide mapping of nucleosome positioning and DNA methylation within Individual DNA molecules
DNA methylation and nucleosome positioning work together to generate chromatin structures that regulate gene expression. Nucleosomes are typically mapped using nuclease digestion requiring significant amounts of material and varying enzyme concentrations. We have developed a method (NOMe-seq) that u...
ORGANISM(S): Homo sapiens 
2012-09-12 | E-GEOD-40770 | biostudies-arrayexpress
TranscriptomicsIdentifying genes dysregulated in patients with acute myocardial infarction
Twenty-three AMI patients and 23 non-AMI healthy controls were included in this pilot study. Tissue samples were cut at 10 μm from formalin fixed paraffin-embedded tissue blocks using a microtome. Six to eight 10-μm sections were used for the isolation procedure. Total RNA isolation was performed us...
ORGANISM(S): Homo sapiens 
2016-05-11 | E-MTAB-3573 | biostudies-arrayexpress
GenomicsEpigenetic Profiling of Human Colorectal Cancer

DNA methylation, together with chromatin modifications, constitute the epigenome that functions to regulate gene expression and genome integrity. DNA methylation alterations are ubiquitous in human cancers, as many genes acquire DNA methylation in a cancer-specific manner. DNA methylation at thes...

phs000385.v1.p1 | EGA
ProteomicsProteomic analysis of patients with advanced triple-negative breast cancer
In the later-line setting or for patients with PD-L1-negative tumors, immunotherapy-based regimens remain ineffective against advanced triple-negative breast cancer (TNBC). In this multicentered phase II trial (NCT04303741), 46 patients with pretreated advanced TNBC were enrolled to receive camreliz...
ORGANISM(S): Homo Sapiens 
2022-05-04 | PXD033655 |
ProteomicsCLOCK regulates Drp1 mRNA stability and mitochondrial homeostasis by interacting with PUF60
This study demonstrated that circadian gene clock plays an important role in the regulation of mitochondrial homeostasis. In this process, CLOCK interacts with PUF60 and affects the mRNA stability of Drp1.
ORGANISM(S): Mus Musculus 
2022-03-31 | PXD032057 |
ProteomicsIntegrated proteomic and transcriptomic analyses reveal the roles of Brucella BI-1 in cell division and membrane homeostasis of Brucella suis S2
To explore the role of Brucella BI-1 in Brucella suis S2, we constructed the Brucella BI-1 deletion mutant strain and its complementary strain. We then determined the effect of Brucella BI-1 deletion on the physiological characteristics of Brucella suis S2 and revealed them via integrated transcript...
ORGANISM(S): Brucella Suis Bv. 1 Str. S2 
2020-11-13 | PXD022537 |
Proteomicsthe proteomics of IGFBP6 in endothelial cells (HUVECs)
To unravel the direct mechanism of the anti-inflammatory effects of IGFBP6 in ECs, we analysed HUVECs treated with either adenovirus-Flag-IGFBP6 (Ad-IGFBP6) or control adenovirus (Ad-NC). We precipitated IGFBP6 from overexpressed ECs followed by mass spectrometry.
ORGANISM(S): Homo Sapiens 
PXD052204 |
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