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MetabolomicsTen Mouse Organs Proteome and Metabolome Atlas from Adult to Aging

The complexity of the aging process, encompassing numerous organs and systems, poses a significant challenge in identifying and targeting key factors that drive age-related decline. The multi-organ synchronous molecular intricacies underlying natural aging remain elusive. Here we presented a data...

2025-08-29 | MTBLS10642 | MetaboLights
MetabolomicsMulti-omic profiles of human nonalcoholic fatty liver disease tissue highlight heterogenic phenotypes
Non-alcoholic fatty liver disease (NAFLD) is a consequence of sedentary life style and high fat diets with an estimated prevalence of about 30% in western countries. It is associated with insulin resistance, obesity, glucose intolerance and drug toxicity. Additionally, polymorphisms in, e.g. APOC3, ...
2015-12-07 | MTBLS174 | MetaboLights
ProteomicsLiver Proteomic Profile in Mice on a High-Fat Diet
Nonalcoholic fatty liver disease (NAFLD) is becoming a primary cause of liver damage in Western society. Nonalcoholic steatohepatitis (NASH) is an advanced stage of NAFLD and may lead to liver cancer. Our previous long-term murine studies have shown the beneficial role of Aquamin, a red marine algae...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-02 | PXD030954 | Pride
Ccn3 High fat Liver cancer Minerals Nash Nafld 
ProteomicsIntegrated liver and plasma proteomics in obese mice reveals complex metabolic and immune regulation
Obesity leads to the development of non-alcoholic fatty liver disease (NAFLD) and associated alterations to the plasma proteome. To elucidate the underlying changes associated with obesity, we performed liquid chromatography-tandem mass spectrometry in the liver and plasma of obese leptin-deficient ...
ORGANISM(S): Mus musculus (Mouse) 
2022-03-01 | PXD026821 | Pride
Proteome Ob/ob Obesity Lcms Nafld 
MetabolomicsMechanisms of hepatic steatosis in chickens: integrated analysis of the host genome, molecular phenomes and gut microbiome

Hepatic steatosis is the initial manifestation of abnormal liver functions and often leads to liver diseases such as non-alcoholic fatty liver disease in humans and fatty liver syndrome in animals. In this study, we conducted a comprehensive analysis of a large chicken population consisting of 70...

2023-07-24 | MTBLS7808 | MetaboLights
ProteomicsProteomic analysis reveals a protective role of specific macrophage subsets in liver repair
Macrophages are a heterogeneous population of immune cells that play central roles in a broad range of biological processes, including the resolution of inflammation. Although diverse macrophage subpopulations have been identified, the characterization and functional specialization of certain macrop...
ORGANISM(S): Mus musculus (Mouse) 
2019-10-08 | PXD011958 | Pride
Macrophage  liver injury  alox15  proteomics 
TranscriptomicsLivers from lean or fat muscle lines fed low or high lipid diets
We used fish from two divergent lines of rainbow trout, selected for low or high muscle fat content (respectively L and F lines) and fed two different diets, containing either 10% (LE diet) or 23% (HE diet) lipids. For more details about experimental fish and diets, see Kolditz et al.,Am J Physiol R...
ORGANISM(S): Oncorhynchus mykiss 
2008-09-01 | E-GEOD-12031 | biostudies-arrayexpress
ProteomicsTST knockout liver proteome iTRAQ and persulfidome
Impaired hepatic glucose and lipid metabolism are hallmarks of type–2 diabetes. Increased sulfide production or sulfide–donor compounds may beneficially regulate hepatic metabolism. Disposal of sulfide through the sulfide oxidation pathway (SOP) is critical for maintaining sulfide within a safe phy...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-11 | PXD028909 | Pride
Persulfidome Liver Proteome Mouse Tst Msms 
ProteomicsSingle or combined dietary supply of Psidium guajava and Phyllanthus amarus extracts differentially modulate immune responses and liver proteome in striped catfish (Pangasianodon hyphophthalmus)
Guava Psidium guajava L (Pg) and bhumi amla Phyllanthus amarus Schum. et Thonn (Pa) are well-known plants in traditional medicine. However, the capacity of these plants for improving the immune system of aquatic species has received less attention so far. This study aimed to investigate the effects ...
ORGANISM(S): Pangasianodon hypophthalmus 
2020-04-09 | PXD018364 | Pride
Liver proteome profile Phyllanthus amarus schum et thonn Psidium guajava l. Humoral immune response Edwardsiella ictaluri Plant extract-based diets Striped catfish. Skin mucosal immune response 
ProteomicsThe role of vagus nerve in liver physiology
Liver metabolism is highly dynamic and is regulated by nutrient availability and humoral factors. A growing body of evidence suggests that the autonomous central nervous system also plays an important role in coordinating hepatic metabolic functions, which confer the flexibility needed for adaptatio...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD041052 | Pride
Liver Proteome Vagus nerve 
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