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ProteomicsSurface and global proteome profiling of osteosarcoma patient derived xenografts
This study analyzed 22 unique OS patient-derived xenografts (PDXs) using proteomics to identify surface proteins for potential immunotherapeutic targeting. Plasma membranes were enriched using density gradient ultracentrifugation and compared to a reference standard of 12 immortalized non-OS cell li...
ORGANISM(S): Homo sapiens (Human) 
2026-07-28 | PXD075484 | Pride
Osteosarcoma 
ProteomicsGlobal proteome analysis of shROR2 MNNG cells
MNNG cells expressing a doxycycline (DOX)-inducible non-targeting shRNA (shCTRL) construct, or three independent shRNA constructs targeting ROR2 (shROR2 1, shROR2 2 and shROR2 3), were grown for 7 days in the presence of 5 µg/ml DOX prior to extraction.
ORGANISM(S): Homo sapiens (Human) 
2026-07-28 | PXD077022 | Pride
Ror2 Osteosarcoma 
UnknownSurface and Global Proteome Analyses Identify ENPP1 and Other Surface Proteins as Actionable Immunotherapeutic Targets in Ewing Sarcoma.
Not available
S-EPMC10905525 | biostudies-literature
ProteomicsA comprehensive evaluation of the Ewing sarcoma surface and global proteomes reveals actionable immunotherapeutic targets.
Ewing sarcoma (EwS) is the second most common bone sarcoma in children, with 1 case per 1.5 million in the United States. While the survival rate of patients diagnosed with localized disease is ~70%, this decreases to ~30% for patients with metastatic disease and only ~10% for treatment refractory d...
ORGANISM(S): Homo sapiens (Human) 
2023-09-29 | PXD043375 | Pride
Ewing sarcoma Surfaceome 
UnknownA MYCN-independent mechanism mediating secretome reprogramming and metastasis in MYCN-amplified neuroblastoma.
Not available
S-EPMC10446492 | biostudies-literature
UnknownProteomic Screens for Suppressors of Anoikis Identify IL1RAP as a Promising Surface Target in Ewing Sarcoma.
Not available
S-EPMC8563374 | biostudies-literature
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