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TranscriptomicsOncogenic BRAFV600E remodels the melanocyte transcriptome and induces BANCR to regulate melanoma cell migration [HT-seq]
Most cancer genomics papers to date have focused on aberrations in genomic DNA and protein-coding transcripts. However, around 50% of transcripts have no coding potential and may exist as non-coding RNA. We performed RNA-seq in BRAFv600e melanoma skin cancer and on melanocytes over-expressing oncoge...
ORGANISM(S): Homo sapiens 
2012-04-28 | E-GEOD-33092 | biostudies-arrayexpress
ProteomicsTargeting the lineage-specific long non-coding RNA LINC01212 as an effective anti-melanoma therapeutic strategy
Focal amplifications of 3p13-3p14 occur in about 10% of melanoma and are associated with poor prognosis. The melanoma-specific oncogene MITF resides at the epicenter of this amplicon1 . However, whether other loci present in this amplicon also contribute to melanomagenesis is unknown. Here we show t...
ORGANISM(S): Homo sapiens (Human) 
2016-01-13 | PXD002565 | Pride
Lncrna protein binding melanoma 
ProteomicsProteogenomic analysis unveils the HLA Class I presented immunopeptidome in melanoma and EGFR mutant lung adenocarcinoma
Immune checkpoint inhibitor and adoptive lymphocyte transfer-based therapies have shown great therapeutic potential for cancers with high tumor mutation burden (TMB). Here, we employed mass spectrometry (MS)-based proteogenomic large-scale profiling to identify potential immunogenic human leukocyte ...
ORGANISM(S): Homo sapiens (Human) 
2021-08-23 | PXD022949 | Pride
Hla immunopeptidome Immunotherapy Neoantigen Melanoma Lung cancer 
ProteomicsLncRNA LINC00622 directly bingding proteins in melanoma cells
We conducted an RNA pulldown assay in melanoma cell line SK-MEL-28 using in vitro-transcribed full-length LINC00622 RNA accompanied with a control EGFP RNA. The specific binding proteins of LINC00622 was identified using high-performance liquid chromatography-mass spectrometry (HPLC-MS).
ORGANISM(S): Homo sapiens (Human) 
2025-07-21 | PXD055040 | Pride
Hplc-ms Linc00622 Melanoma Human 
Transcriptomicscis regulated role of lncRNA in transcriptional or developmental process (ChIRP-Seq)
We report that long noncoding RNAs contribute to transcription and developmental process. Thousands of lncRNAs have been identified in the whole genome, and tend to located closely to protein-coding genes. To study position relationship between lncRNA and protein-coding genes, we classified all of l...
ORGANISM(S): Mus musculus 
2016-03-24 | E-GEOD-79541 | biostudies-arrayexpress
TranscriptomicsEvx1as and EVX1 knockouts by CRISPR
We report that long noncoding RNAs contribute to transcription and developmental process. Thousands of lncRNAs have been identified in the whole genome, and tend to located closely to protein-coding genes. To study position relationship between lncRNA and protein-coding genes, we classified all of l...
ORGANISM(S): Mus musculus 
2016-03-24 | E-GEOD-70419 | biostudies-arrayexpress
TranscriptomicsEssential role of lncRNA binding for WDR5 maintenance of active chromatin and embryonic stem cell pluripotency
Here we delineate the roles of RNA binding for WDR5 function on chromatin state and murine embryonic stem cell (ESC) maintenance. Examination of global transcriptional changes and mapping genome-wide transcription factors occupancy at distinct time points during the transdifferentiation process
ORGANISM(S): Mus musculus 
2014-02-12 | E-GEOD-53035 | biostudies-arrayexpress
TranscriptomicsAirn transcriptional overlap but not its lncRNA products induce imprinted Igf2r silencing.
To test if the imprinted long non-coding RNA (lncRNA) Airn transcription or its product silences the protein-coding Igf2r gene, we shortened the endogenous lncRNA to four different lengths by inserting polyadenylation (polyA) cassettes on the paternal chromosome via homologous recombination in ES ce...
ORGANISM(S): Mus musculus 
2012-12-20 | E-GEOD-41444 | biostudies-arrayexpress
UnknownLINC01116 promotes nascent protein synthesis and cellular stemness through the miR-432-5p/FKBP7/14 regulatory axis in melanoma.
Not available
S-EPMC12727800 | biostudies-literature
UnknownLncRNA DANCR Enhances Angiogenesis to Promote Melanoma Progression Via Sponging miR-5194.
Not available
S-EPMC10197948 | biostudies-literature
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