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MetabolomicsRedox proteomics reveal a role for peroxiredoxinylation in stress protection.

The redox state of proteins is essential for their function and guarantees cell fitness. Peroxiredoxins protect cells against oxidative stress, maintain redox homeostasis, act as chaperones, and transmit hydrogen peroxide signals to redox regulators. Despite the profound structural and functional...

2025-07-17 | MTBLS11979 | MetaboLights
ProteomicsLocus-specific proteomics identifies CHD4 and Polycomb PRC1 as novel repressors of Epstein-Barr virus lytic reactivation
The Epstein Barr virus (EBV) is a human gammaherpesvirus which infects over 90% of the global population and is associated with lymphoid and epithelioid cancers. After infection, EBV enters a latent state in B-cells where the viral genome persists as a nuclear episome maintained by expression of a s...
ORGANISM(S): Homo sapiens (Human) 
2026-02-11 | PXD068122 | Pride
Epigenetics Virus activation Locus specific proteomics Polycomb complex Epstein-barr virus Virus latency Nurd complex De-ubiquitinase 
ProteomicsLocus-specific Retention Predictor (LsRP)
LsRP based on amino acid locus information and Support Vector Regression can be used to predict peptide retention time in LC-MS experiments.
ORGANISM(S): Homo sapiens (Human) 
2017-04-10 | PXD005572 | Pride
Prediction Peptide retention Lc-msms 
ProteomicsSingle-copy locus proteomics of early- and late-firing DNA replication origins identifies a role of Ask1/DASH complex in replication timing control
The chromatin at origins of replication is thought to influence DNA replication initiation in eukaryotic genomes. However, it remains unclear how the chromatin composition controls the firing of early-efficient (EE) or late-inefficient (LI) origins. Here, we used site-specific recombination and sing...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-02-16 | PXD032930 | Pride
Locus-specific chromatin isolation  site-specific recombination  affinity purification  dna replication origin  replication timing  replication efficiency  origin chromatin structure  dash complex  ask1 protein  microtubule cytoskeleton 
ProteomicsLocus-specific proteomics identification of OCT4 regulators
We set out to develop an unbiased, genome-wide method to screen for proteins that locate to the OCT4 proximal enhancer (PE) in hESCs; for this purpose, we developed an optimized locus-specific proteomics approach in hESCs. First, we designed TALEN (Transcription Activator-Like Effector Nuclease) con...
ORGANISM(S): Homo sapiens (Human) 
2019-01-07 | PXD010963 | Pride
Oct4 Lc-msms Talen Cross-linking 
GenomicsCombined SNPs sequencing and allele specific proteomics capture reveal functional causality underpinning the 2p25 prostate cancer susceptibility locus
Combined SNPs sequencing and allele specific proteomics capture reveal functional causality underpinning the 2p25 prostate cancer susceptibility locus
PRJNA1212024 | ENA
UnknownLocus-specific Retention Predictor (LsRP): A Peptide Retention Time Predictor Developed for Precision Proteomics.
Not available
S-EPMC5356008 | biostudies-literature
ProteomicsSingle-copy locus isolation identifies distinct proteomes of early- and late-firing DNA replication origin chromatin
The chromatin at origins of replication is the template for DNA replication initiation in eukaryotic genomes. However, whether the chromatin composition instructs individual origins to fire early-efficiently (EE) or late-inefficiently (LI) remains to be investigated. Here, we used site-specific reco...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-05-10 | PXD031984 | Pride
Replication timing Replication efficiency Affinity purification Locus-specific chromatin isolation Dna replication origin Histone ptms Site-specific recombination 
ProteomicsSex Differences in Single Neuron Function and Proteomics Profiles Examined by Patch-Clamp and Mass Spectrometry in the Locus Coeruleus of the Adult Mouse
Aims: This study aimed to identify and characterize the intrinsic properties of locus coeruleus (LC) noradrenergic neurons in male and female mice using a genetic approach. We also sought to investigate sex-specific differences in membrane properties, action potential generation, and protein express...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-24 | PXD045844 | Pride
Neuronal excitability Single-cell proteomics Noradrenergic neurons Locus coeruleus Sex-differences 
UnknownAllele-specific quantitative proteomics unravels molecular mechanisms modulated by cis-regulatory PPARG locus variation.
Not available
S-EPMC5389726 | biostudies-literature
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