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ProteomicsA quantitative proteomics study for assessing rodent thyroid toxicity
Here, we aimed to use TMT based quantitative proteomics approach to investigate rodent thyroid toxicity. For this purpose, male Wistar rats have been exposed to a direct (6-propyl-2-thiouracil, PTU) and an indirect (phenytoin) thyroid toxicant, respectively. Thereby, two doses (high, low) and three ...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-10-25 | PXD026835 | Pride
Tmt Toxicity Phenytoin Ptu Thyroid 
TranscriptomicsTranscription profiling of Atlantic salmon fed with a low, medium or high histidine diet
Atlantic salmon at their 2nd year in sea were fed with a low, medium or high histidine diet (L, M, and H, respectively) for several months. Samples were taken at three time points, after the first, second and third period, and a number of fishes were assigned to a new feed group following a crossove...
ORGANISM(S): Salmon salar 
2009-03-27 | E-TABM-678 | biostudies-arrayexpress
ProteomicsQuantitative phosphoproteomics study for assessing rodent thyroid toxicity
Here, we aimed to apply a TMT based quantitative phosphoproteomics approach to investigate rodent thyroid toxicity. For this purpose, male Wistar rats have been exposed to a direct (6-propyl-2-thiouracil, PTU) and an indirect (phenytoin) thyroid toxicant, respectively. Thereby, two doses (low:5ppm f...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-10-25 | PXD030254 | Pride
Phosphoproteomics  liver  tmt Thyroid toxicity  ptu Phenytoin 
ProteomicsSeasonally relevant changes in UV-A alter neurohormone levels and behavior via cOpsin1
Many animals exhibit strong seasonal rhythms in their physiology and behavior, but the sensors conveying the environmental input are still unknown. In our study we provide detailed light measurements from the natural habitat of the marine bristle worm Platynereis dumerilii, showing that the ratios b...
ORGANISM(S): Platynereis Dumerilii 
PXD014682 | panorama
UnknownChanges in the Prevalence of Child and Youth Mental Disorders and Perceived Need for Professional Help between 1983 and 2014: Evidence from the Ontario Child Health Study.
Not available
S-EPMC6463358 | biostudies-literature
TranscriptomicsOmeprazole stimulated gene expression in rats
Omeprazole stimulated gene expression in rats Samples and RNA preparation: The series is composed of 9 hybridizations for analysis of differentially expressed genes in the gastric mucosa of omeprazole dosed vs. control rats. Nine rats (200-250 g) were given (by gavage) 400 micromol/kg of the proton ...
ORGANISM(S): Rattus norvegicus 
2010-06-05 | E-GEOD-1808 | biostudies-arrayexpress
UnknownConnecting the data landscape of long-term ecological studies: The SPI-Birds data hub.
Not available
S-EPMC8518542 | biostudies-literature
GenomicsThe histone methyltransferase activity of MLL1 is dispensable for hematopoiesis and leukemogenesis
Despite correlations between histone methyltransferase (HMT) activity and gene regulation, direct evidence that HMT activity is responsible for gene activation is sparse. We address the role of the HMT activity for MLL1, a histone H3 lysine 4 (H3K4) methyltransferase critical for maintaining hematop...
ORGANISM(S): Mus musculus 
2014-04-03 | E-GEOD-56456 | biostudies-arrayexpress
ProteomicsEvaluating linear ion trap incorporation for MS3-based multiplexed single-cell proteomics
The project aims to evaluate the use of a linear ion trap to increase the sensitivity of multiplexed single-cell proteomics. Using diluted mouse peptide samples from C10 and Raw, we compared the proteome coverages, data missingness, and quantification performance between linear ion trap and Orbitrap...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-08-22 | MSV000090178 | MassIVE
TranscriptomicsHuman PC-3 prostate cancer cells: Control (shNTC; non-target shRNA) vs. shETV4 knock down (shETV4)
Transcriptional profiling of human PC-3 prostate cancer cells lentivirally infected with non-target control (NTC) short hairpin (sh)RNA comparing with lentivirally shRNA mediated human ETV4 knock-down. Cells were either cultured for 24 hours at 20% oxygen tension or 0.2% oxygen. Goal was to determin...
ORGANISM(S): Homo sapiens 
2011-12-06 | E-GEOD-32385 | biostudies-arrayexpress
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