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TranscriptomicsTranscription profiling of rats treated with chronic doses of anti-epilepsy drugs to identify genes involved in epileptogenesis
Epilepsy is a major neurological disorder that affects approximately 1% of the population. The processes that lead to the development of epilepsy (epileptogenesis) are largely unknown. Levetiracetam is a novel antiepileptic drug (AED) that in the kindling model inhibits epileptogenesis in addition t...
ORGANISM(S): Rattus norvegicus 
2007-08-01 | E-GEOD-2880 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat brain after prolonged administration of Phenytoin
In order to elucidate the molecular mechanisms of action of Phenytoin, we examined by microarrays the effects of prolonged administration of Phenytoin on gene expression in hippocampus and frontal cortex of Sprague-Dawley rats chronically treated with Phenytoin.
ORGANISM(S): Rattus norvegicus 
2009-12-31 | E-MEXP-1728 | biostudies-arrayexpress
UnknownDoes long-term phenytoin have a place in Dravet syndrome?
Not available
S-EPMC9735367 | biostudies-literature
UnknownPrevention of phenytoin-induced gingival overgrowth by lovastatin in mice.
Not available
S-EPMC4450317 | biostudies-literature
UnknownPhenytoin inhibits necroptosis.
Not available
S-EPMC5834524 | biostudies-literature
UnknownCritical Excipient Properties for the Dissolution Enhancement of Phenytoin.
Not available
S-EPMC6868594 | biostudies-literature
ProteomicsQuantitative phosphoproteomics study for assessing rodent thyroid toxicity
Here, we aimed to apply a TMT based quantitative phosphoproteomics approach to investigate rodent thyroid toxicity. For this purpose, male Wistar rats have been exposed to a direct (6-propyl-2-thiouracil, PTU) and an indirect (phenytoin) thyroid toxicant, respectively. Thereby, two doses (low:5ppm f...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-10-25 | PXD030254 | Pride
Phosphoproteomics  liver  tmt Thyroid toxicity  ptu Phenytoin 
UnknownComprehensive Physiologically Based Pharmacokinetic Model to Assess Drug-Drug Interactions of Phenytoin.
Not available
S-EPMC10609929 | biostudies-literature
UnknownNew mechanisms of phenytoin in calcium homeostasis: competitive inhibition of CD38 in hippocampal cells.
Not available
S-EPMC6279657 | biostudies-literature
UnknownTherapeutic hypothermia decreases phenytoin elimination in children with traumatic brain injury.
Not available
S-EPMC3783553 | biostudies-literature
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