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Transcriptomicsshort and long attack latency mice
Two wild house mice lines were genetically selected for short and long attack latency. Mice with an attack latency <50s or >600s were considered short attack latency mice (SAL) and long attack latency mice(LAL) respectively. RNA from the hippocampus of 14 SAL or 14 LAL mice was pooled and used as in...
ORGANISM(S): Mus musculus 
2003-10-30 | E-GEOD-786 | biostudies-arrayexpress
ProteomicsEarly Cardiac Proteomic Profiling in a Long-Latency Doxorubicin Cardiomyopathy Model Exhibits Sexual Dimorphism for Cardioprotection
In this study, we employed large-scale data-independent acquisition (DIA) proteomics in a long-latency rat model of doxorubicin-induced cardiomyopathy to characterize early cardiac proteomic remodeling prior to overt functional decline. Male and female Sprague-Dawley rats received a cumulative low d...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-09-14 | PXD076815 | Pride
Doxorubicin Dia Proteomics Female Long latency Male Data-independent acquisition Cardiomyopathy 
ModelsAguilera 2014 - HIV latency. Interaction between HIV proteins and immune response
Aguilera 2014 - HIV latency. Interaction between HIV proteins and immune response This model is described in the article: Studying HIV latency by modeling the interaction between HIV proteins and the innate immune response. Aguilera LU, Rodríguez-González J. J. Theor. Biol...
2024-09-02 | BIOMD0000000573 | BioModels
ProteomicsCBX4 contributes to HIV-1 latency by forming phase-separated nuclear bodies and SUMOylating EZH2
Molecular mechanisms of HIV-1 latency have been studied extensively to achieve a functional cure for the acquired immunodeficiency syndrome (AIDS). To develop more promising latency-reversing agents (LRAs) to efficiently reactivate the latent reservoir which is subsequently eliminated by immune surv...
ORGANISM(S): Homo Sapiens 
2022-01-14 | PXD031011 |
Transcriptomicsshort and long attack latency mice
Two wild house mice lines were genetically selected for short and long attack latency. Mice with an attack latency <50s or >600s were considered short attack latency mice (SAL) and long attack latency mice(LAL) respectively. RNA from the hippocampus of 14 SAL or 14 LAL mice was pooled and used as in...
ORGANISM(S): Mus musculus 
2003-10-31 | GSE786 | GEO
TranscriptomicsThe role of antigen presenting cells in the induction of HIV-1 latency in resting CD4+ T-cells
BACKGROUND: Combination antiretroviral therapy (cART) is able to control HIV-1 viral replication, however long-lived latent infection in resting memory CD4+ T-cells persist. The mechanisms for establishment and maintenance of latent infection in resting memory CD4+ T-cells remain unclear. Previously...
ORGANISM(S): Homo sapiens 
2015-12-23 | E-GEOD-70106 | biostudies-arrayexpress
GenomicsIdentification of Host Biomarkers of EBV Latency IIb and Latency III
Identification of Host Biomarkers of EBV Latency IIb and Latency III
PRJNA546009 | ENA
ProteomicsCAF-1 promotes HIV-1 latency by leading the formation of phase-separated suppressive nuclear bodies
HIV-1 latency is a major obstacle to achieve a functional cure for AIDS. To eradicate the viral reservoir, one of the strategies is to specifically reactivate HIV-1-infected cells and followed by elimination with potent immune surveillance. However, present latency-reversing agents (LRAs) are quite ...
ORGANISM(S): Homo Sapiens 
2021-02-09 | PXD024172 |
ProteomicsTrans cohorts metabolic reprograming towards glutaminolysis in long-term successfully treated HIV-Infection: potential role in accelerated aging and latency reversal
Despite successful combination antiretroviral therapy (cART), persistent low-grade immune activation together with inflammation and toxic antiretroviral drugs can lead to long-lasting metabolic flexibility and adaptation in people living with HIV (PLWH). Our study investigated alterations in the pla...
ORGANISM(S): Homo sapiens (Human) 
2021-11-24 | PXD028531 | Pride
Latency Hiv-infection Antiretroviral therapy Glutaminolysis Aging 
GenomicsMus musculus
short and long attack latency mice
PRJNA87753 | ENA
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