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ProteomicsAortic smooth muscle cells in bicuspid valve patients
and with higher incidence if associated to bicuspid aortic valve (BAV) for unknown reasons. TAA is usually diagnosed fortuitously and the lack of effective drug therapy to delay progression and avoid dissection lies in the limited knowledge of pathophysiology. Objectives. We aimed to identify the mo...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD043062 | Pride
Aortic aneurysm  bicuspid aortic valve  cardiovascular disease  vascular smooth muscle cells  proteomics 
Proteomicsurinary glycopeptide profile differentiates early cardiorenal risk in subjects not meeting criteria for chronic kidney disease
Early diagnosis and treatment of chronic kidney disease (CKD) is a worldwide challenge. Albuminuria is defined as urinary albumin:creatinine ratio (ACR) ≥30 mg/g. Subjects with ACR values below this cut-off and preserved renal function are considered at no cardiorenal risk, but increased risk is est...
ORGANISM(S): Homo sapiens (Human) 
2025-06-02 | PXD049688 | Pride
Urine  glycopeptide  chronic kidney disease  early cardiorenal risk albuminuria 
ProteomicsHost sensing of microbially produced imidazole propionate is a driver and therapeutic 1 target in atherosclerosis
Atherosclerosis is the main underlying cause of cardiovascular diseases (CVDs). Its prevention is based on the detection and treatment of traditional cardiovascular risk factors1 but often fails to identify individuals at risk for early vascular disease2. Recent research has suggested new players in...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-15 | PXD063955 | Pride
Atherosclerosis Human Imidazole propionate Microbiota 
ProteomicsAbsence of MCJ/DnaJC15 promotes brown adipose tissue thermogenesis
Obesity poses a global health challenge, demanding a deeper understanding of adipose tissue (AT) and its mitochondria. This study describes the role of the mitochondrial protein Methylation-controlled J protein (MCJ/DnaJC15) in orchestrating brown adipose tissue (BAT) thermogenesis. Here we show how...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-13 | PXD057026 | Pride
Proeomics Mouse Lipidomics Adipose tissue 
ProteomicsLoss of stromal Gαq fosters oral cancer progression
Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive cancer, with limited therapeutic options and a high mortality rate, primarily due to metastasis and recurrence. Tumor-stroma interactions, and namely cancer-associated fibroblasts (CAFs), are pivotal in shaping HNSCC progression. C...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-27 | PXD061641 | Pride
Human Exosome Oral cancer Stromal gαq 
ProteomicsPERK crosstalk between ER and microtubule dynamics
The architecture of the endoplasmic reticulum (ER) is tightly controlled as a key determinant of its function. Its dynamics are linked to those of the cytoskeleton, but our understanding of how this coordination occurs and what its functional relevance is, is limited. We found the Unfolded Protein R...
ORGANISM(S): Homo sapiens (Human) 
2025-11-03 | PXD057012 | Pride
Human Endoplasmic reticulum (er) Unfolded protein response 
UnknownInstant Cascara Beverage as a Neuroimmune Modulator of the Brain-Gut Axis: Sex-Dependent Effects in Healthy Rats.
Not available
S-EPMC12609599 | biostudies-literature
UnknownClinical and Virological Features of SARS-CoV-2 Variants during the Four Waves of the Pandemic in the Mexican Southeast.
Not available
S-EPMC10053031 | biostudies-literature
UnknownOpinions and perceptions of patients with cardiovascular disease on adherence: a qualitative study of focus groups.
Not available
S-EPMC10870481 | biostudies-literature
Unknown[Incubation period of COVID-19: A systematic review and meta-analysis].
Not available
S-EPMC7528969 | biostudies-literature
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