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MetabolomicsLeptin increases hepatic triglyceride export via a vagal mechanism in humans
Recombinant human leptin (metreleptin) reduces hepatic lipid content in patients with lipodystrophy and overweight patients with non-alcoholic fatty liver disease and relative hypoleptinemia independent of its anorexic action. In rodents, leptin signaling in the brain increases very-low-density lipo...
2023-06-07 | MTBLS4231 | MetaboLights
UnknownSpeeding up Viedma Deracemization through Water-catalyzed and Reactant Self-catalyzed Racemization.
Not available
S-EPMC7497082 | biostudies-literature
TranscriptomicsRNA-seq of mouse wounds from different time points, treatment and genotype
We investigated transcriptional changes in wounds of wild-type and transgenic mice with either a lack or an overabundance of skin lymphatic vessels. Further, we investigated transcriptional changes in diabetic wounds of db/db mice treated with either F8-SIP or F8-VEGF-C.
ORGANISM(S): Mus musculus 
2023-02-07 | E-MTAB-12545 | biostudies-arrayexpress
ProteomicsEpitope mapping of an anti-plasmodium pfMSP119 antibody by Intact Transition Epitope Mapping - Targeted High-Energy Rupture of Extracted Epitopes
Rapid diagnostic tests are first line assays for diagnosing infectious diseases, such as malaria. To minimize false positive and false negative test results in population screening assays, high quality reagents and well characterized antigens and antibodies are needed. An important property of ant...
ORGANISM(S): Homo sapiens (Human) 
2020-08-24 | PXD019717 | Pride
Plasmodium falciparum Epitope mapping Assembled epitope Malaria screening Pfmsp119 antigen 
ProteomicsEpitope fine mapping by mass spectrometry: Investigations of immune complexes consisting of monoclonal anti-HpTGEKP antibody and zinc finger protein linker phospho-hexapeptides.
We describe the mass spectrometric analysis of the binding strength of a monoclonal mouse antibody (clone 18E9.D9, BioLegend, London, England) which was raised against the predominantly occuring phosphorylated linker sequence, HpTGEKP, of C2H2 zinc finger proteins (ZNF proteins) using a synthetic ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-15 | PXD031150 | Pride
Item-two Off-line esi-ms Zinc finger-phosphopeptide Antiphosphopeptide-antibody Binding strength characterization 
UnknownAssociation of Expanded VA Hospice Care With Aggressive Care and Cost for Veterans With Advanced Lung Cancer.
Not available
S-EPMC6567823 | biostudies-literature
UnknownThe experience of providing hospice care concurrent with cancer treatment in the VA.
Not available
S-EPMC6391175 | biostudies-literature
TranscriptomicsIdentification and Targeted Inhibition of a Fibroblast Lineage Responsible for Scarring and Cancer Stroma
Dermal fibroblasts represent a heterogeneous population of cells with diverse features that remain largely undefined due to a lack of functional subclasses. Here we reveal the presence of multiple lineages of dermal fibroblasts within the dorsal back. Genetic lineage tracing and transplantation assa...
ORGANISM(S): Mus musculus 
2015-05-15 | E-GEOD-65402 | biostudies-arrayexpress
TranscriptomicsContribution of the STAT1alpha and STAT1beta isoforms to IFN-gamma mediated innate immunity
The transcription factor STAT1 is essential for interferon- (IFN) mediated protective immunity in humans and mice. Two splice isoforms of STAT1, STAT1M-NM-1 and STAT1M-NM-2, differ with regard to a C-terminal transactivation domain, which is absent in STAT1M-NM-2. Dimers of STAT1M-NM-2 are therefore...
ORGANISM(S): Mus musculus 
2014-04-04 | E-GEOD-48970 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of S. cerevisiae response to the antifungal compound sampangine
Sampangine, a plant-derived alkaloid found in the Annonaceae family, exhibits strong inhibitory activity against the opportunistic fungal pathogens Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus. In the present study, transcriptional profiling experiments coupled with the analy...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-11 | E-GEOD-10073 | biostudies-arrayexpress
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