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ProteomicsCommon and distinct pathophysiological processes associated to ileal and colonic ulcers in Crohn’s disease
Based on genetic risk factors and natural history, Crohn’s disease (CD) can be separated in two entities, an ileal and a colonic disease. Protein based-approaches are needed to elucidate whether such subphenotypes are related to distinct pathophysiological processes. In this work, we compared the pr...
ORGANISM(S): Homo sapiens (Human) 
2019-07-15 | PXD012284 | Pride
Proteomics Ulcer Colon Crohn’s disease Ileum 
ProteomicsFibrosis associated changes detected in the proteome of surface epithelium overlying Crohn’s Disease Strictures
Background and aims: Intestinal fibrosis is a common complication of Crohn’s disease (CD). It is characterised by an excessive accumulation of fibroblasts differentiating into activated myofibroblasts secreting excessive extracellular matrix. The potential role of the intestinal epithelium in this f...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD022214 | Pride
Inflammatory bowel disease Label free proteomics Surface epithelium Fibrostenosis Ileum 
ProteomicsDiscovery of potential early colorectal cancer biomarker
Differential analysis of proteomes originated from early lesion of colorectal cancer and colon control tissue using FFPE-FASPTM and Label free analysis using 2DnanoUPLC separation before analysis on a qTOF synapt HDMS G2 using ion mobility as supplementary separation dimension
ORGANISM(S): Homo sapiens (Human) 
2017-03-28 | PXD005735 | Pride
Pt2nm Early stage Ffpe-fasp Human colorectal cancer Pt1nm Label free 
ProteomicsSolute carrier family 12 member 2 as a proteomic and histological biomarker of dysplasia and neoplasia in ulcerative colitis
Ulcerative colitis (UC) patients have a greater risk of developing colorectal cancer through inflammation-dysplasia-carcinoma sequence of transformation. The histopathological diagnosis of dysplasia is therefore of critical clinical relevance, but dysplasia may be difficult to distinguish from infla...
ORGANISM(S): Homo sapiens (Human) 
2020-09-16 | PXD018679 | Pride
Dysplasia associated to inflammation Colorectal neoplasia Label-free proteomics 
UnknownSimultaneous ventilation in the Covid-19 pandemic. A bench study.
Not available
S-EPMC7815120 | biostudies-literature
TranscriptomicsToxin-antitoxin of Rickettsia determines fatal addiction of the host cells
Rickettsia spp. can cause mild to severe human disease. These intracellular bacteria are associated with arthropods, nematodes and trematodes, and usually, are efficiently transmitted transovarially to the progeny of the invertebrate host. We recently demonstrated foreign gene acquisition by lateral...
ORGANISM(S): Homo sapiens 
2012-05-23 | E-GEOD-22072 | biostudies-arrayexpress
UnknownImpact of species and antibiotic therapy of enterococcal peritonitis on 30-day mortality in critical care-an analysis of the OUTCOMEREA database.
Not available
S-EPMC6731585 | biostudies-literature
UnknownInvestigating Predictive Factors of Suicidal Re-attempts in Adolescents and Young Adults After a First Suicide Attempt, a Prospective Cohort Study. Study Protocol of the SURAYA Project.
Not available
S-EPMC9276973 | biostudies-literature
UnknownCharacterization of an autosomal dominant bleeding disorder caused by a thrombomodulin mutation.
Not available
S-EPMC4342361 | biostudies-literature
UnknownHepatitis C virus (HCV) genotypes in the Caribbean island of Martinique: evidence for a large radiation of HCV-2 and for a recent introduction from Europe of HCV-4.
Not available
S-EPMC344442 | biostudies-literature
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