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ProteomicsThe structure and composition of native human nucleosomes
In this study, we analysed the composition of histone modifications on native nucleosomes purified from HEK293 cells.
ORGANISM(S): Homo sapiens (Human) 
2026-01-12 | PXD064241 | Pride
Ptms Cryoem Nucleosomes Histones 
ProteomicsThe BRD4-nucleosome interaction is enhanced modestly and non-selectively by histone acetylation
BRD4 regulates gene transcription in complex eukaryotes, in part through the binding of its tandem bromodomains to acetylated lysine residues found in histones and transcription factors. Despite pharmacological inhibition of these binding events showing significant promise in preclinical studies, cl...
ORGANISM(S): Homo sapiens (Human) 
2026-01-12 | PXD064221 | Pride
Histone Nucleosome Ptms Acetylation Brd4 
ProteomicsTargeting cholesterol homeostasis eliminates drug-tolerant persister cells in glioblastoma
The transition of cancer cells between drug-sensitive and drug-tolerant persister phenotypes drives treatment failures. Using glioblastoma models, we identified MRK-740, an inhibitor of H3K4 methyltransferase PRDM7/9, as a potent enhancer of chemotherapy-induced cell death, resulting in elimination ...
ORGANISM(S): Homo sapiens (Human) 
2025-12-22 | PXD050643 | Pride
Gliobastomas Histones Microtubule-targeting agents 
ProteomicsThe Bloom’s syndrome helicase BLM functions as a homodimer within the Bloom’s complex
Homologous recombination (HR) is an essential and highly regulated cellular process. Unintended HR in somatic cells is potentially deleterious; it can result in translocations and/or somatic cell loss of heterozygosity. This is suppressed by the BLM protein in combination with topoisomerase III, RM...
ORGANISM(S): Homo sapiens (Human) 
2022-01-17 | PXD011078 | Pride
Blm Crosslinking ms Structural proteomics Bloom’s syndrome 
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