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TranscriptomicsSexually dimorphic gene expression emerges with embryonic genome activation and is dynamic throughout development (RNA-seq)
As sex determines mammalian development, understanding the nature and developmental dynamics of the sexually dimorphic transcriptome is important. To explore this, we generated 72 genome-wide RNA-seq profiles from mouse eight-cell embryos, late gestation and adult livers, together with 4 ground-stat...
ORGANISM(S): Mus musculus 
2015-05-26 | E-GEOD-58733 | biostudies-arrayexpress
GenomicsSexually dimorphic gene expression emerges with embryonic genome activation and is dynamic throughout development
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-05-26 | E-GEOD-59222 | biostudies-arrayexpress
TranscriptomicsBuccals are likely to be a more informative surrogate tissue than blood for epigenome-wide association studies [Illumina tiling]
There is increasing evidence that interindividual epigenetic variation is an etiological factor in common human diseases. Such epigenetic variation could be genetic or non-genetic in origin, and epigenome-wide association studies (EWASs) are underway for a wide variety of diseases/phenotypes. Howeve...
ORGANISM(S): Homo sapiens 
2013-05-02 | E-GEOD-46573 | biostudies-arrayexpress
GenomicsSexually dimorphic gene expression emerges with embryonic genome activation and is dynamic throughout development (ChIP-seq)
As sex determines mammalian development, understanding the nature and developmental dynamics of the sexually dimorphic transcriptome is important. To explore this, we generated 72 genome-wide RNA-seq profiles from mouse eight-cell embryos, late gestation and adult livers, together with 4 ground-stat...
ORGANISM(S): Mus musculus 
2015-05-26 | E-GEOD-59220 | biostudies-arrayexpress
GenomicsBuccals are likely to be a more informative surrogate tissue than blood for epigenome-wide association studies [Bisulfite-Seq]
There is increasing evidence that interindividual epigenetic variation is an etiological factor in common human diseases. Such epigenetic variation could be genetic or non-genetic in origin, and epigenome-wide association studies (EWASs) are underway for a wide variety of diseases/phenotypes. Howeve...
ORGANISM(S): Homo sapiens 
2013-05-02 | E-GEOD-46572 | biostudies-arrayexpress
UnknownPhase I Dose-Escalation Trial of PT2385, a First-in-Class Hypoxia-Inducible Factor-2α Antagonist in Patients With Previously Treated Advanced Clear Cell Renal Cell Carcinoma.
Not available
S-EPMC5946714 | biostudies-literature
UnknownEGFR Inhibition Enhances the Cellular Uptake and Antitumor-Activity of the HER3 Antibody-Drug Conjugate HER3-DXd.
Not available
S-EPMC8732289 | biostudies-literature
TranscriptomicsBuccals are likely to be a more informative surrogate tissue than blood for epigenome-wide association studies
There is increasing evidence that interindividual epigenetic variation is an etiological factor in common human diseases. Such epigenetic variation could be genetic or non-genetic in origin, and epigenome-wide association studies (EWASs) are underway for a wide variety of diseases/phenotypes. Howeve...
ORGANISM(S): Homo sapiens 
2013-03-28 | E-GEOD-45529 | biostudies-arrayexpress
TranscriptomicsA CellAge epigenetic clock for expedited discovery of anti-ageing compounds in vitro
We aim to improve anti-ageing drug discovery, currently achieved through laborious and lengthy longevity analysis. Recent studies demonstrated that the most accurate molecular method to measure human age is based on CpG methylation profiles, as exemplified by several epigenetics clocks that can accu...
ORGANISM(S): Homo sapiens 
2021-10-01 | E-MTAB-8327 | biostudies-arrayexpress
UnknownPosterior cortical atrophy phenotypic heterogeneity revealed by decoding 18F-FDG-PET.
Not available
S-EPMC8600283 | biostudies-literature
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