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MetabolomicsLipidomics in the serum of cold exposed mice treated with 12-LOX inhibitor LOXBlock-1
Not available
ORGANISM(S): Mus musculus 
ST001207 | MetabolomicsWorkbench
ProteomicsA highly potent bi-thiazole inhibitor of LOX rewires collagen architecture and enhances chemoresponse in triple-negative breast cancer
The assessment of global changes in fibrillar collagens and to the larger extent e.g., ECM induced upon inhibitor treatment has largely been lacking for the currently available LOX family inhibitors. We therefore undertook a quantitative pharmacodynamics approach to characterize the global alteratio...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-01 | PXD052642 | Pride
Lox inhibitor Collagen architecture Ros Lysyl oxidase Fak Tnbc chemoresistance 
ProteomicsA highly potent bi-thiazole inhibitor of LOX rewires collagen architecture and enhances chemoresponse in triple-negative breast cancer
Matrix-assisted laser desorption/ionization-mass spectrometry imaging (MALDI-MSI) data investigating changes in extracellular matrix/collagen architecture of mouse tumor tissue in response to LOX inhibition. Sample Key: Vehicle, Doxo (Chemotherapy drug), 6403 (LOX inhibitor), Combo (Doxo + LOX inhib...
ORGANISM(S): Mus musculus (Mouse) 
2024-07-25 | PXD052657 | Pride
Lox inhibitor Mouse Lysyl oxidase Tnbc chemoresistance 
ProteomicsIntraductal xenografts reveal LOX inhibitor PXS-5505 as a translatable targeting strategy for lobular carcinoma exploiting a unique vulnerability
Fifteen percent of breast cancers are invasive lobular carcinomas (ILCs), a specific histological subtype. Although ILCs have distinct clinicopathological features and pathognomonic CDH1 loss, no specific therapies exist because ILCs are underrepresented in clinical trials and preclinical models are...
ORGANISM(S): Homo sapiens (Human) 
2026-01-29 | PXD065164 | Pride
Pxs-5505 Lobular carcinoma Lox inhibitor 
ProteomicsA highly potent bi-thiazole inhibitor of LOX rewires collagen architecture and enhances chemoresponse in triple-negative breast cancer
Raw proteomic files Metin C, Saatci O, Rezaeian A-H, Rao CN, Beneker C, Taylor H, Pederson B, Chatzistamou I, Buckley B, Lessner S, Angel P, McInnes C, Sahin O. A highly potent bi-thiazole inhibitor of LOX rewires collagen architecture and enhances chemoresponse in triple-negative breast cancer. Ce...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-05-16 | MSV000094776 | MassIVE
GenomicsActivation of Piezo1-mediated mechanotransduction by LOX promotes neuronal ferroptosis leading to HIBD and discovery of LOX inhibitor TA
Activation of Piezo1-mediated mechanotransduction by LOX promotes neuronal ferroptosis leading to HIBD and discovery of LOX inhibitor TA
PRJNA1127495 | ENA
TranscriptomicsLOXs in invasive trophoblasts
Human placental development is characterized by invasion of extravillous cytotrophoblasts (EVCTs) into the uterine wall during the first trimester of pregnancy. Peroxisome proliferator-activated receptor gamma (PPARG) plays a major role in placental development, and activation of PPARG by its agonis...
ORGANISM(S): Homo sapiens 
2013-12-04 | E-GEOD-28426 | biostudies-arrayexpress
ProteomicsLOX inhibition creates vulnerability to ferroptosis by decoupling glucose metabolism and mitophagy in triple-negative breast cancer
High degree of metabolic heterogeneity and plasticity of triple-negative breast cancer (TNBC) contribute to its aggressiveness and resistance to standard therapies, necessitating identification of novel therapeutic vulnerabilities. Here, we identify non-canonical functions of an ECM remodeler protei...
ORGANISM(S): Homo sapiens (Human) 
2026-07-06 | PXD071741 | Pride
Mitophagy Tnbc Er-mitochondria contacts (mercs) Dhodh Ferroptosis Lysyl oxidase (lox) Glucose metabolism 
UnknownHuman 15-LOX-1 active site mutations alter inhibitor binding and decrease potency.
Not available
S-EPMC5065787 | biostudies-literature
TranscriptomicsThe maize death acids, 10-oxo-11-phytoenoic acid and derivatives, are rapidly induced phytoalexins with multiple biological activities
Plant cellular damage promotes the interaction of lipoxygenases (LOX) with free fatty acids to yield 9- and 13-hydroperoxides which are further metabolized into diverse oxylipins. The enzymatic action of 13-LOX on linolenic acid enables production of 12-oxo-phytodienoic acid (12-OPDA) and its downst...
ORGANISM(S): Zea mays 
2015-08-13 | E-GEOD-68589 | biostudies-arrayexpress
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