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Neural crest cells are multipotent cells that delaminate from the neuroepithelium, migrating throughout the embryo. Aberrant migration causes developmental defects. Animal models are improving our understanding of neural crest anomalies, but in vivo migration behaviours are poorly understood. Here, ...
ORGANISM(S): Homo sapiens (Human) 
2023-10-05 | PXD044150 | Pride
Gene expression of PCSM-LPD
Primary cutaneous CD4+ small or medium T-cell lymphoproliferative disorder (PCSM-LPD) is a clonal T-cell proliferation disease confined to the skin. PCSM-LPD shares expression of T-follicular T helper cell (Tfh) markers with various mature T-cell lymphomas. However, the benign presentation of PCSM-L...
ORGANISM(S): Homo sapiens 
2023-11-06 | GSE243819 | GEO
Microglia activation is a key modulator of brain vulnerability in response to intra-uterine growth restriction (IUGR). However, the consequences of IUGR on microglia development and on microglia proteome are still unknown. We used a model of IUGR induced by a gestational low-protein diet (LPD) in ra...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-12-17 | PXD028950 | Pride
Single-nucleus RNA-seq reveals reprogrammed hepatocytes that express c-Met/β-catenin oncogenes in LPD-fed mice.
To further interrogate the impact of low protein diet (LPD) on the c-Met/β-catenin expressing hepatocytes, we performed single-nucleus RNA-sequencing (snRNA-seq) analysis. Mice were fed on chow diet (CD) or LPD for one week, followed by SB-HTVI of c-Met/β-catenin. Two weeks post SBHTVI, 42,277 singl...
ORGANISM(S): Mus musculus 
2025-12-08 | GSE311624 | GEO
Genomics
LPD-3 regulated transcriptome in C. elegans
We performed bulk RNA-seq to compare liver tissues from 4 groups of mice: vector control fed with CD, c-Met/β-cat mice fed with CD, vector control fed with LPD, and c- Met/β-cat mice fed with LPD. Differential gene expression and gene set enrichment analyses (GSEA) were performed and identified two ...
ORGANISM(S): Mus musculus 
2025-12-08 | GSE310077 | GEO
Bulk RNA-seq of the CD and LPD-fed mice injected with vector control or c-Met/ΔN90-β-catenin by SB-HTVI
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