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GenomicsPseudomonas sp. LRP2-20
Pseudomonas sp. strain LRP2-20 complete genome sequencing project
PRJDB13593 | ENA
ProteomicsIntegrative structural analysis defines how LRPAP1 modulates ligand binding in LRP2
The low density lipoprotein receptor-related protein 2 (LRP2 or megalin) is a multiligand endocytic receptor implicated in the homeostasis of several organs. Mutations in the LRP2 gene are associated with severe systemic disease. It is well-know that the low density lipoprotein receptor-related prot...
ORGANISM(S): Homo sapiens (Human) 
2026-03-21 | PXD066532 | Pride
Crosslinking ms Cross-linking ms Megalin Lrpap1 Xl-ms Endocytosis Lrp2 Rap 
ProteomicsIntegrative structural analysis defines how LRPAP1 modulates ligand binding in LRP2 (Dataset 3)
The low density lipoprotein receptor-related protein 2 (LRP2 or megalin) is a multiligand endocytic receptor implicated in the homeostasis of several organs. Mutations in the LRP2 gene are associated with severe systemic disease. It is well-know that the low density lipoprotein receptor-related prot...
ORGANISM(S): Homo sapiens (Human) 
2026-03-21 | PXD066538 | Pride
Crosslinking ms Cross-linking ms Megalin Lrpap1 Xl-ms Endocytosis Lrp2 Rap 
ProteomicsIntegrative structural analysis defines how LRPAP1 modulates ligand binding in LRP2 (Dataset 1)
The low density lipoprotein receptor-related protein 2 (LRP2 or megalin) is a multiligand endocytic receptor implicated in the homeostasis of several organs. Mutations in the LRP2 gene are associated with severe systemic disease. It is well-know that the low density lipoprotein receptor-related prot...
ORGANISM(S): Homo sapiens (Human) 
2026-03-21 | PXD066475 | Pride
Crosslinking ms Cross-linking ms Megalin Lrpap1 Xl-ms Endocytosis Lrp2 Rap 
GenomicsLRP2 gene silencing expression by in vitro shRNA delivery on human iRPE cells
LRP2 gene silencing expression by in vitro shRNA delivery on human iRPE cells
PRJNA1164753 | ENA
GenomicsClusterin is protective for liver fibrosis through mesothelial-specific LRP2 receptor mediated endocytosis
Clusterin is protective for liver fibrosis through mesothelial-specific LRP2 receptor mediated endocytosis
PRJNA985580 | ENA
TranscriptomicsLRP2 gene silencing expression by in vitro shRNA delivery on human iRPE cells
To investigate the consequence of LRP2 loss-of-function in RPE cells in non-syndromic myopia, we differentiated IPS cells into iRPE in which the LRP2 gene was knocked out by shRNA.
ORGANISM(S): Homo sapiens 
2025-06-06 | GSE277911 | GEO
TranscriptomicsProteolytic processing of LRP2 on RPE cells regulates BMP activity to control eye size and refractive error
We compare dissected ocular tissues from wild-type and lrp2-/- mutant adult zebrafish in order to examine the genetic pathways underlying the enlarged eye phenotype observed in the absence of Lrp2. ABSTRACT: Mutations in LRP2, a transmembrane receptor, cause ocular enlargement and high-myopia. LRP2 ...
ORGANISM(S): Danio rerio 
2018-06-01 | GSE97125 | GEO
TranscriptomicsClusterin is protective for liver fibrosis through mesothelial-specific LRP2 receptor mediated endocytosis
During liver fibosis, the CLU protein was overexpressed of hepatocytes. Loss of function perform showed that CLU is protective for liver fibrosis. Mechanismly, we found LRP2 postive cells were increased after hrCLU administration in fibrotic CLUKO mice. Then single cell analysis domenstrated that LR...
ORGANISM(S): Mus musculus 
2024-06-01 | GSE235221 | GEO
UnknownRadiolabeled 15-mer peptide internalization is mediated by megalin (LRP2 receptor) in a CRISPR/Cas9-based LRP2 knockout human kidney cell model.
Not available
S-EPMC11026318 | biostudies-literature
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