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ProteomicsIntegrative structural analysis defines how LRPAP1 modulates ligand binding in LRP2
The low density lipoprotein receptor-related protein 2 (LRP2 or megalin) is a multiligand endocytic receptor implicated in the homeostasis of several organs. Mutations in the LRP2 gene are associated with severe systemic disease. It is well-know that the low density lipoprotein receptor-related prot...
ORGANISM(S): Homo sapiens (Human) 
2026-03-21 | PXD066532 | Pride
Crosslinking ms Cross-linking ms Megalin Lrpap1 Xl-ms Endocytosis Lrp2 Rap 
ProteomicsIntegrative structural analysis defines how LRPAP1 modulates ligand binding in LRP2 (Dataset 3)
The low density lipoprotein receptor-related protein 2 (LRP2 or megalin) is a multiligand endocytic receptor implicated in the homeostasis of several organs. Mutations in the LRP2 gene are associated with severe systemic disease. It is well-know that the low density lipoprotein receptor-related prot...
ORGANISM(S): Homo sapiens (Human) 
2026-03-21 | PXD066538 | Pride
Crosslinking ms Cross-linking ms Megalin Lrpap1 Xl-ms Endocytosis Lrp2 Rap 
ProteomicsIntegrative structural analysis defines how LRPAP1 modulates ligand binding in LRP2 (Dataset 1)
The low density lipoprotein receptor-related protein 2 (LRP2 or megalin) is a multiligand endocytic receptor implicated in the homeostasis of several organs. Mutations in the LRP2 gene are associated with severe systemic disease. It is well-know that the low density lipoprotein receptor-related prot...
ORGANISM(S): Homo sapiens (Human) 
2026-03-21 | PXD066475 | Pride
Crosslinking ms Cross-linking ms Megalin Lrpap1 Xl-ms Endocytosis Lrp2 Rap 
GenomicsRNA-Seq analysis of Wild Type and lrpap1-/- zebrafish eyes at three month
RNA-Seq analysis of Wild Type and lrpap1-/- zebrafish eyes at three month
PRJNA776645 | ENA
UnknownLRPAP1 autoantibodies in mantle cell lymphoma are associated with superior outcome.
Not available
S-EPMC8351899 | biostudies-literature
UnknownLRPAP1 is released from activated microglia and inhibits microglial phagocytosis and amyloid beta aggregation.
Not available
S-EPMC10687467 | biostudies-literature
UnknownLrpap1 deficiency leads to myopia through TGF-β-induced apoptosis in zebrafish
Not available
S-EPMC9580148 | biostudies-literature
UnknownSerum anti-LRPAP1 is a common biomarker for digestive organ cancers and atherosclerotic diseases.
Not available
S-EPMC7734161 | biostudies-literature
UnknownThe B-cell Receptor Autoantigen LRPAP1 Can Replace Variable Antibody Regions to Target Mantle Cell Lymphoma Cells.
Not available
S-EPMC8274796 | biostudies-literature
UnknownSecreted LRPAP1 binds and triggers IFNAR1 degradation to facilitate virus evasion from cellular innate immunity.
Not available
S-EPMC10518340 | biostudies-literature
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