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TranscriptomicsDiscovery of novel recurrent mutations and rearrangements in early T-cell precursor acute lymphoblastic leukemia by whole genome sequencing
Early T-cell precursor acute lymphoblastic leukaemia (ETP ALL) is an aggressive malignancy of unknown genetic basis. We performed whole genome sequencing of tumour and normal DNA from 12 children with ETP ALL and assessed the frequency of somatic alterations in 52 ETP and 42 non-ETP T-ALL samples by...
ORGANISM(S): Homo sapiens 
2011-11-23 | E-GEOD-28703 | biostudies-arrayexpress
UnknownSafety and efficacy of re-treatment with [177Lu]Lu-DOTA-Octreotate radionuclide therapy in progressive gastro-entero-pancreatic neuroendocrine tumours - a single centre experience.
Not available
S-EPMC12316713 | biostudies-literature
MetabolomicsDiel metabolomics analysis of a hot spring chlorophototrophic microbial mat leads to new hypotheses of community member metabolisms
Dynamic environmental factors such as light, nutrients, salt, and temperature continuously affect chlorophototrophic microbial mats, requiring adaptive and acclimative responses to stabilize composition and function. Quantitative metabolomics analysis can provide insights into metabolite dynamics fo...
2024-02-23 | MTBLS187 | MetaboLights
GenomicsThe maize methylome modulates mRNA splicing and reveals widespread paramutation guided by small RNA.
Methylation of chromosomal DNA in animals and plants is a fundamental mechanism of epigenetic regulation, and the maize genome, with its diverse complement of transposons and repeats, is a paradigm for transgenerational mechanisms such as paramutation and imprinting. We have determined the genome-wi...
ORGANISM(S): Zea mays 
2013-06-03 | E-GEOD-39232 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human acute myelogenous leukemia stem cells reveals disregulated gene networks
We performed the first genome-wide expression analysis directly comparing the expression profile of highly enriched normal human hematopoietic stem cells (HSC) and leukemic stem cells (LSC) from patients with acute myeloid leukemia (AML). Comparing the expression signature of normal HSC to that of L...
ORGANISM(S): Homo sapiens 
2009-08-12 | E-GEOD-17054 | biostudies-arrayexpress
ProteomicsNovel KEAP1 activator targeting C151 enhances CUL3 binding and decreases NRF2
Novel KEAP1 activator targeting C151 enhances CUL3 binding and decreases NRF2
ORGANISM(S): Homo sapiens (Human) 
2025-12-10 | PXD056257 | Pride
Nrf2 Keap1 Cul3 
TranscriptomicsNeonatal Skeletal Progenitors
Prospectively isolated and characerized skeletal progenitor lineages 3 repeats per FACS sorted population
ORGANISM(S): Mus musculus 
2015-01-29 | E-GEOD-64447 | biostudies-arrayexpress
UnknownNo evidence of pitavastatin effect on muscle area or density among people with HIV.
Not available
S-EPMC12313271 | biostudies-literature
ProteomicsSkeletal Muscle TFEB Signaling Promotes Central Nervous System Function and Reduces Neuroinflammation during Aging and Neurodegenerative Disease
Skeletal muscle has recently arisen as a novel regulator of Central Nervous System (CNS) function and aging, secreting bioactive molecules known as myokines with metabolism-modifying functions in targeted tissues, including the CNS. Here we report the generation of a novel transgenic mouse with enha...
ORGANISM(S): Mus Musculus 
2023-12-06 | PXD045241 | panorama
TranscriptomicsGene expression profiling in Salmonella Typhimurium stimulated heterophils using a chicken 44K Agilent microarray
To determine the host response to Salmonella Typhimurium (ST) in heterophils, a whole chicken genome array was used to analyze RNA isolated from heterophils stimulated in vitro with ST (30 min, 1 h, 2 h, and 3 h) or medium control (NS). Dual-color, direct comparisons were carried between ST-stimulat...
ORGANISM(S): Gallus gallus 
2010-04-13 | E-GEOD-14684 | biostudies-arrayexpress
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