Sort   by:  
 Page size 
UnknownAfatinib restrains K-RAS-driven lung tumorigenesis.
On the basis of clinical trials using first-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), it became a doctrine that V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (K-RAS) mutations drive resistance to EGFR inhibition in non-small cell lung cancer ...
S-EPMC7610658 | biostudies-literature
UnknownTargeted sequencing of plasmacytoid urothelial carcinoma reveals frequent TERT promoter mutations.
Activating mutations in the promoter of the telomerase reverse transcriptase (TERT) gene are the most common genetic alterations in urothelial carcinoma (UC) of the bladder and upper urinary tract. Although the cadherin 1 (CDH1) gene is commonly mutated in the clinically aggressive plasmacytoid vari...
S-EPMC6728909 | biostudies-literature
UnknownPredicting drug susceptibility of non-small cell lung cancers based on genetic lesions.
Somatic genetic alterations in cancers have been linked with response to targeted therapeutics by creation of specific dependency on activated oncogenic signaling pathways. However, no tools currently exist to systematically connect such genetic lesions to therapeutic vulnerability. We have therefor...
S-EPMC2689116 | biostudies-literature
UnknownReduced decline of lung diffusing capacity in COPD patients with diabetes and metformin treatment.
We studied whether in patients with COPD the use of metformin for diabetes treatment was linked to a pattern of lung function decline consistent with the hypothesis of anti-aging effects of metformin. Patients of GOLD grades 1-4 of the COSYCONET cohort with follow-up data of up to 4.5 y were include...
S-EPMC8792053 | biostudies-literature
ProteomicsResuscitation from the viable but nonculturable state of Escherichia coli: the importance of a pyruvate sensing network
Viable but nonculturable (VBNC) organisms have been underestimated and neglected when studying dormant phenotypes. In clinical settings, VBNC cells may contribute to non-apparent infections capable of being reactivated after months or even years, as for the case of Mycobacterium tuberculosis. The la...
ORGANISM(S): Escherichia coli 
2018-11-23 | PXD009463 | Pride
Heterogeneity Metabolism Oxidative stress Scavenging 
UnknownDissecting the genetics of the human transcriptome identifies novel trait-related trans-eQTLs and corroborates the regulatory relevance of non-protein coding loci†.
Genetics of gene expression (eQTLs or expression QTLs) has proved an indispensable tool for understanding biological pathways and pathomechanisms of trait-associated SNPs. However, power of most genome-wide eQTL studies is still limited. We performed a large eQTL study in peripheral blood mononuclea...
S-EPMC4512630 | biostudies-literature
ProteomicsProteome analysis of Corynebacterium glutamicum ATCC13032 Δefp
Bacterial translational elongation factor P (EF-P) is required during translation of proteins containing consecutive proline motifs. Several transcription and translational regulators contain polyproline motifs and therefore, EF-P might also affect levels of proteins that do not contain polyproline ...
ORGANISM(S): Corynebacterium glutamicum ATCC 13032 
2020-04-06 | PXD014742 | Pride
Ef-p Corynebacterium glutamicum Actinobacteria Elongation factor p 
UnknownIntegration of Genome-Wide SNP Data and Gene-Expression Profiles Reveals Six Novel Loci and Regulatory Mechanisms for Amino Acids and Acylcarnitines in Whole Blood.
Profiling amino acids and acylcarnitines in whole blood spots is a powerful tool in the laboratory diagnosis of several inborn errors of metabolism. Emerging data suggests that altered blood levels of amino acids and acylcarnitines are also associated with common metabolic diseases in adults. Thus, ...
S-EPMC4581711 | biostudies-literature
ProteomicsFunction and Regulation of the pyruvate transporter CstA in Escherichia coli
Pyruvate is a central metabolite that connects many metabolic pathways in living organisms. To meet the cellular pyruvate requirements, Escherichia coli most likely has three pyruvate uptake systems, BtsT, YhjX and CstA. Transport studies in intact cells proved that CstA is a high specific pyruvate ...
ORGANISM(S): Escherichia coli 
2020-12-02 | PXD021798 | Pride
Catabolite repression Stationary phase Pyruvate uptake Global regulator fis 
UnknownRelationship between impaired BMP signalling and clinical risk factors at early-stage vascular injury in the preterm infant.

Introduction

Chronic lung disease, that is, bronchopulmonary dysplasia (BPD) is the most common complication in preterm infants and develops as a consequence of the misguided formation of the gas-exchange area undergoing prenatal and postnatal injury. Subsequent vascular disease and its prog...
S-EPMC9685723 | biostudies-literature
Sort   by:  
 Page size