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TranscriptomicsGrhl2 regulated genes in the mouse lung epithelial MLE15 cell line
The Grainyhead family of transcription factors controls morphogenesis and differentiation of epithelial cell layers in multicellular organisms by regulating cell junction- and proliferation-related genes. Grainyhead-like 2 (Grhl2) is expressed in developing mouse lung epithelium and is required for ...
ORGANISM(S): Mus musculus 
2012-09-10 | E-GEOD-40729 | biostudies-arrayexpress
UnknownA phase Ib/II dose expansion study of subcutaneous sasanlimab in patients with locally advanced or metastatic non-small-cell lung cancer and urothelial carcinoma.
Not available
S-EPMC10485400 | biostudies-literature
UnknownEfficacy of Early Prophylaxis Against Catheter-Associated Thrombosis in Critically Ill Children: A Bayesian Phase 2b Randomized Clinical Trial.
Not available
S-EPMC7902342 | biostudies-literature
TranscriptomicsSingle-cell RNA-seq analysis of cutaneous wound healing in mouse
Studying the transcriptomic response of different epidermal stem cell populations to wounding has been difficult due to intermixing of wound healing and homeostastic cells from different stem cell pools in bulk-cell sequencing setups. Here, we circumvent those problems by using a single-cell sequenc...
ORGANISM(S): Mus musculus 
2018-04-01 | E-MTAB-6583 | biostudies-arrayexpress
GenomicsChIP-seq experiment to determine the genomic binding sites of mutant V5-tagged ZFHX2 R1913K protein in a stable-expressing human SH-SY5Y neuroblastoma cell line
A novel missense mutation has been identified in a human pain-insensitive family in the gene ZFHX2. We modelled this mutation in mice by changing the orthologous amino acid and carried out pain behaviour tests in mutant BAC transgenic mice. These showed a phenotype of hyposensitivity to noxious ther...
ORGANISM(S): Homo sapiens 
2018-06-11 | E-MTAB-5651 | biostudies-arrayexpress
TranscriptomicsBulk RNA-seq of the human malaria parasite Plasmodium falciparum 3D7 cultured under different iron conditions
Background: Host iron deficiency is protective against severe malaria as the human malaria parasite Plasmodium falciparum depends on free iron from its host to proliferate. Due to the absence of transferrin, ferritin, ferroportin, and a functional heme oxygenase, the parasite’s essential pathways of...
ORGANISM(S): Plasmodium falciparum 
2024-04-08 | E-MTAB-13411 | biostudies-arrayexpress
TranscriptomicsRNA sequencing revealed novel actors of the acquisition of drug resistance in Candida albicans
Drug susceptible clinical isolates of Candida albicans frequently become highly tolerant to drugs during chemotherapy, with dreadful consequences on patient health. We used RNA sequencing (RNA-seq) to analyze the transcriptomes of a CDR (Candida Drug Resistance) strain and its isogenic drug sensitiv...
ORGANISM(S): Candida albicans 
2012-09-04 | E-GEOD-38298 | biostudies-arrayexpress
TranscriptomicsDNA methylation profiling of healthy elderly individuals with different lifestyle habits
Illumina Infinium EPIC HumanMethylation BeadChip data from saliva DNA samples from a healthy elderly cohort with individuals in the age range 70-95 in Southwest Sweden. The cohort was stratified into study groups based on participants´answers to a questionnaire of different lifestyle factors includi...
ORGANISM(S): Homo sapiens 
2022-07-23 | E-MTAB-11445 | biostudies-arrayexpress
UnknownTuberculosis in otherwise healthy adults with inherited TNF deficiency.
Not available
S-EPMC11390478 | biostudies-literature
UnknownShared heritability and functional enrichment across six solid cancers.
Not available
S-EPMC6347624 | biostudies-literature
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