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TranscriptomicsRNA-seq time series of lung epithelial and lung mesenchymal cells in a novel co-culture model of lung fibrosis
The interaction of lung epithelial and lung mesenchymal cells (fibroblasts) was investigated in a novel co-culture model of human pulmonary fibrosis. Remarkably, co-culturing both cell types induced cell-type-specific responses, including fibroblast-to-myofibroblast differentiation and epithelial-to...
ORGANISM(S): Homo sapiens 
2022-10-03 | E-MTAB-11832 | biostudies-arrayexpress
TranscriptomicsExpression profiling of murine lung 70 days following exposure to fractionated or acute dose of 1.0 Gy 56Fe- particle irradiation
Irradiation of the K-rasLA1 mouse model with a fractionated dose of 1.0Gy 56Fe- particles increases the incidence of invasive carcinoma compared to unirradiated controls or those irradiated with an acute dose. Microarray profiling was perfromed on whole lungs from K-rasLA1 mice in order to determin...
ORGANISM(S): Mus musculus 
2014-09-22 | E-GEOD-42233 | biostudies-arrayexpress
ProteomicsLC7 Proteomic Analysis of Matched Control and NSCLC Lung Adenocarcinoma Tissue.
Non-small cell lung adenocarcinoma is the most frequently diagnosed lung cancer type and remains the leading cause of cancer mortality for men and women in the United States. Management of lung cancer is hindered by high false-positive rates due to the inability to resolve benign versus malignant tu...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080825 | MassIVE
TranscriptomicsTranslational co-culture model reveals epithelial-mesenchymal mechanisms of lung fibrosis and identifies NF-κB as potential therapeutic target
The interaction of lung epithelial and lung mesenchymal cells was investigated in a novel co-culture model of human pulmonary fibrosis. Remarkably, co-culturing both cell types induced cell-type-specific responses, including fibroblast-to-myofibroblast differentiation and epithelial-to-mesenchymal t...
ORGANISM(S): Homo sapiens 
2022-10-03 | E-MTAB-11847 | biostudies-arrayexpress
ProteomicsDepletion of histone methyltransferase KMT9 inhibits lung cancer cell proliferation by inducing non-apoptotic cell death
Background: Lung cancer is the leading cause of cancer related death worldwide. Over the past 15 years no major improvement of survival rates could be accomplished. The recently discovered histone methyltransferase KMT9 as epigenetic regulator of prostate tumor growth has now raised hopes of enablin...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD014145 | Pride
Kmt9 Non-small cell lung cancer Proteomics Epigenetics Histone methyltransferase Lung cancer A549 Transcriptomics 
TranscriptomicsGene expression analysis of lung cancer samples and healthy controls
Non-small cell lung cancer (NSCLC, n=22) and normal adjacent control biopsies (n=18) from patients with lung cancer were obtained for Affymetrix GeneChip analysis. NSCLC samples were grouped into squamous cell carcinoma (SCC, n=11) and adenocarcinoma (AC, n=11) samples.
ORGANISM(S): Homo sapiens 
2017-07-01 | E-MTAB-5231 | biostudies-arrayexpress
ProteomicsM.musculus - Lung, iBAQ (Angelidisetal,natcommun.2019)
abundance based on iBAQ, Interaction consistency score: 8.7, Coverage: 21
ORGANISM(S): 10090 
2019-00-00 | 386924191 | PAXDB
MetabolomicsMulti-omics toxicity profiling of engineered nanomaterials

This study aims to implement methods for toxicological profiling of engineered nanomaterials using toxicogenomics, proteomics, and metabolomics along with computational analyses. For all three omics layers the human cell lines A549 (lung epithelial cells) and THP1 (monocytes) were separately expo...

2016-12-05 | MTBLS277 | MetaboLights
ProteomicsM.musculus - Lung, iBAQ (Angelidisetal,natcommun.2019)
abundance based on iBAQ, Interaction consistency score: 9.7, Coverage: 21
ORGANISM(S): 10090 
2019-00-00 | 3284560666 | PAXDB
ProteomicsProteomic analysis of lung metastases in a murine breast cancer model reveals divergent influence of CTSB and CTSL overexpression
Proteomic analysis of lung metastases in a murine breast cancer model reveals divergent influence of CTSB and CTSL overexpression.
ORGANISM(S): Mus musculus (Mouse) 
2017-12-04 | PXD005860 | Pride
Breast cancer Dimethyl-labelling Murine Metastasis 
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