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TranscriptomicsHuman lung squamous cell carcinoma expression profiling
Lung squamous cell carcinoma gene expression (LSCC) is highly variable. This study discovered and validated LSCC gene expression subtypes. RNA from tumors and a common reference were hybridized to Agilent two color microarrays
ORGANISM(S): Homo sapiens 
2010-08-06 | E-GEOD-17710 | biostudies-arrayexpress
ProteomicsHuman- lung squamous cell carcinoma LC-MS/MS Orbitrap Fusion
Integration of LC-MS/MS data links biological processes to fragmentation of tumor epithelia, and morphological marker that associates with decreased patient survival in lung squamous cell carcinoma
ORGANISM(S): Homo sapiens (Human) 
2017-05-15 | PXD006132 | Pride
Human Lung squamous cell carcinoma Fusion 
TranscriptomicsRNA-seq of Tumor Initiating Cells (TICs) from Lung Squamous Cell Carcinoma (LSCC) lines reveals PRKCI dependent Hedgehog (HH) Signalling
RNA-seq analysis was performed on TICs and the parental counterparts of 4 LSCC cell lines. In addition, PRKCI knock down (KD) variants of these cells were sequenced. Subsequent analysis revealed that activation of HH signaling, a known driver of the TIC phenotype, is dependent on PRKCI expression. E...
ORGANISM(S): Homo sapiens 
2014-03-28 | E-GEOD-48599 | biostudies-arrayexpress
TranscriptomicsLSCC
The basaloid carcinoma (pure) and the (mixed) basalod variant of lung squamous cell carcinoma (SCC) have a dismal prognosis but their underlying specific molecular characteristics remain obscure and no therapy has proven to be efficient. In order to assess their molecular specificity among other lun...
ORGANISM(S): Homo sapiens 
2014-11-17 | E-MTAB-2435 | biostudies-arrayexpress
ProteomicsUSP28 deletion and small molecule inhibition destabilises c-Myc and elicits regression of squamous cell lung carcinoma
Lung squamous cell carcinoma (LSCC) is a considerable global health burden, with an incidence of over 600,000 cases per year. Treatment options are limited, and patient 5-year survival rate is less than 5%. The ubiquitin specific protease 28 (USP28) has been implicated in tumorigenesis through its s...
ORGANISM(S): Homo sapiens (Human) 
2024-07-30 | PXD023339 | Pride
Abpp Usp28 Lung squamous cell carcinoma (lscc) 
TranscriptomicsGenome-wide microRNA expression profiling identifies miR-9-3 and miR-193a as targets for DNA methylation in non-small cell lung cancers
Purpose: The major aim of this study was to investigate the role of DNA methylation (referred to as methylation) on microRNA (miRNA) silencing in non-small cell lung cancers (NSCLC). Experimental Design: We performed microarray expression analyses of 856 miRNAs in NSCLC A549 cells before and after t...
ORGANISM(S): Homo sapiens 
2012-03-13 | E-GEOD-31579 | biostudies-arrayexpress
TranscriptomicsMicroRNA Profiling Analysis and Target Gene Prediction in Laryngeal Squamous Cell Carcinoma
Objective: The purpose of this study was to investigate the miRNAs basis of tumorigenesis in LSCC, and analyze the physiological processes of target genes predicted by the screened miRNAs that may be useful for the effective therapeutic strategies. Methods: A total number of 6 patients who underwent...
ORGANISM(S): Homo sapiens 
2014-10-30 | E-GEOD-62819 | biostudies-arrayexpress
TranscriptomicsHuman lung squamous cell carcinoma expression profiling
Lung squamous cell carcinoma gene expression (LSCC) is highly variable. This study discovered and validated LSCC gene expression subtypes.
ORGANISM(S): Homo sapiens 
2010-08-06 | GSE17710 | GEO
GenomicsCD271 is preferentially expressed and essential for cell proliferation in squamous cell carcinoma of the lung
CD271 is preferentially expressed and essential for cell proliferation in squamous cell carcinoma of the lung
PRJNA484690 | ENA
GenomicsPredicting the metabolomic impact of deregulated microRNAs in lung squamous cell carcinoma
Predicting the metabolomic impact of deregulated microRNAs in lung squamous cell carcinoma
PRJNA627878 | ENA
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