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TranscriptomicsA TLR- and non-TLR-mediated innate response to lentiviruses restricts hepatocyte entry and can be ameliorated by pharmacological blockade
Lentiviral vector (LV)-mediated gene transfer is a promising method of gene therapy. We previously reported that systemic injection of LV triggers a transient inflammatory response. Here, we carried out studies to better characterize this response, and to develop a strategy to overcome the effects o...
ORGANISM(S): Mus musculus 
2013-07-05 | E-GEOD-39129 | biostudies-arrayexpress
ProteomicsThe atrial and ventricular myocardial proteome of end-stage lamin heart disease
Background: Lamins A/C (encoded by the LMNA gene) can lead to dilated cardiomyopathy (DCM). Objectives: This study sought to undertake proteomic analysis of myocardial tissue to explore the postgenomic phenotype of end-stage lamin heart disease. Methods: Consecutive patients with end-stage lamin...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD040488 | Pride
Lamin Human Heart 
TranscriptomicsCardiac mesenchymal stromal cells from right and left ventricles display different biological properties.
Aims. We sought to analyze the physiological differences of human C-MSC between the left ventricle (LV) versus the right ventricle (RV) . Methods and results. Autoptic cardiac specimens from LV and RV were obtained from healthy donors. Part was used for tissue sections; part was processed to obtain ...
ORGANISM(S): Homo sapiens 
2020-05-01 | GSE142205 | GEO
UnknownPathophysiology of LV Remodeling Following STEMI: A Longitudinal Diffusion Tensor CMR Study.
Not available
S-EPMC9902278 | biostudies-literature
ProteomicsProteome Analysis of Avian Metapneumovirus C Type infected Vero cells by iTRAQ coupled with LC-MS
To date, no study has been carried out to assess the protein profiles of aMPV/C-infected cells. In the present study, iTRAQ combined with LC-MS/MS was used to reveal the global proteomic changes occurring in Vero cells in response to aMPV/C infection for the first time and to help understand the mol...
ORGANISM(S): Cercopithecus aethiops (Green monkey) (Grivet) 
2020-04-03 | PXD017827 | Pride
Vero cells Lc-ms Ampv/c 
TranscriptomicsTranscription profiling of mouse model of heart failure rescued by beta-adrenergic receptor kinase (betaARKct), vs heart failure and untreated samples
Numerous murine models of heart failure (HF) have been described, many of which develop progressive deterioration of cardiac function. We have recently demonstrated that several of these can be "rescued" or prevented by transgenic cardiac expression of a peptide inhibitor of the beta-adrenergic rece...
ORGANISM(S): Mus musculus 
2007-12-13 | E-GEOD-670 | biostudies-arrayexpress
UnknownPalladium-Catalyzed C-H Arylation and Azetidination of Pentacyclic Triterpenoids.
Not available
S-EPMC12242664 | biostudies-literature
TranscriptomicsDeep RNA Sequencing Reveals Dynamic Regulation of Myocardial Noncoding RNA in Failing Human Heart and Remodeling with Mechanical Circulatory Support
Complete transcriptome profiling in human failing and non-failing control hearts using next-gen sequencing Poly-A selected RNA and small RNA sequencing carried out in 5 groups of samples: NF, ICM, NICM, ICM+LVAD, NICM+LVAD
ORGANISM(S): Homo sapiens 
2014-02-10 | E-GEOD-46224 | biostudies-arrayexpress
UnknownMultiplex detection of six swine viruses on an integrated centrifugal disk using loop-mediated isothermal amplification.
Not available
S-EPMC6838697 | biostudies-literature
ProteomicsProphylactic or therapeutic NAD+ repletion can prevent or rescue HFpEF, but dietary intervention and weight loss cannot
Left ventricular (LV) diastolic dysfunction is a hallmark of Heart Failure with preserved Ejection Fraction (HFpEF), an escalating global health challenge. We demonstrated selective depletion of the oxidized form of nicotinamide adenine dinucleotide (NAD+) and the rate-limiting enzyme of the NAD+ bi...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-09 | PXD033027 | Pride
Mouse Heart 
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