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ProteomicsNuclear release of eIF1 globally increases stringency of start codon selection to preserve mitotic arrest physiology
Regulated start codon selection has the potential to reshape the proteome through the differential production of uORFs, canonical proteins, and alternative translational isoforms. However, conditions under which start codon selection is altered remain poorly defined. Here, using transcriptome-wide t...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054179 | Pride
Translation Ribosomes Mitosis Cell cycle 
ProteomicsNuclear release of eIF1 globally increases stringency of start codon selection to preserve mitotic arrest physiology
Regulated start codon selection has the potential to reshape the proteome through the differential production of uORFs, canonical proteins, and alternative translational isoforms. However, conditions under which start codon selection is altered remain poorly defined. Here, using transcriptome-wide t...
ORGANISM(S): Homo sapiens (Human) 
2024-10-07 | PXD054183 | Pride
Translation Ribosomes Mitosis Cell cycle 
ProteomicsAlternative start codon selection shapes mitochondrial function during evolution, homeostasis, and disease
Mitochondrial acquisition was a pivotal event in eukaryotic evolution, requiring core proteins adapt to function both within the mitochondria and in the host cell. Here, we systematically profile the localization of protein isoforms generated by alternative start codon selection. We identify hundred...
ORGANISM(S): Homo sapiens (Human) 
2025-10-28 | PXD062112 | Pride
Mrps38 Ribosomes Mitochondria Aurkaip1 
Proteomics5′ UTR length regulates the production of alternative N-terminal protein isoforms in health and disease
The 5′ untranslated region (5′ UTR) of an mRNA is classically viewed as a regulatory region that controls the amount of protein production, but not the resulting protein sequence. Here, we demonstrate that 5′ UTR length also plays a direct role in alternative N-terminal protein isoform production by...
ORGANISM(S): Homo sapiens (Human) 
2026-03-13 | PXD073007 | Pride
Cfd Translation initiation Alternative n-terminal isoform 
ProteomicsSRSF12 is a primate-specific splicing factor that induces a tissue-specific gene expression program
Alternative splicing expands proteomic diversity and is tightly regulated by splicing factors, including the serine/arginine-rich (SR) protein family. Here, we analyze the poorly characterized protein SRSF12. Although SRSF12 is conserved across vertebrates, it is poorly expressed in most mammals, an...
ORGANISM(S): Homo sapiens (Human) 
2026-01-05 | PXD066334 | Pride
Splicing Ip-ms Srsf 
UnknownValidation and Disease Risk Assessment of Previously Reported Genome-Wide Genetic Variants Associated With Brugada Syndrome: SADS-TW BrS Registry.
Not available
S-EPMC7439932 | biostudies-literature
ProteomicsChinese Hamster Ovary cell proteins co-purified with recombinant HIV-1 envelopes, part 2
Chinese Hamster Ovary (CHO) cells are frequently used to produce recombinant HIV envelope protein gp120. In this study, we characterized the CHO proteins that become co-purified with gp120 when lectin affinity chromatography is used. Many of co-purified CHO proteins identified were extracellular m...
ORGANISM(S): Cricetulus Griseus (ncbitaxon:10029) 
2018-01-25 | MSV000081975 | MassIVE
ProteomicsChinese Hamster Ovary cell proteins co-purified with recombinant HIV-1 envelopes, part 3
Chinese Hamster Ovary (CHO) cells are frequently used to produce recombinant HIV envelope protein gp120. In this study, we characterized the CHO proteins that become co-purified with gp120 when lectin affinity chromatography is used. Many of co-purified CHO proteins identified were extracellular m...
ORGANISM(S): Cricetulus Griseus (ncbitaxon:10029) 
2018-02-14 | MSV000082065 | MassIVE
ProteomicsChinese Hamster Ovary cell proteins co-purified with recombinant HIV-1 envelopes, part 1
Chinese Hamster Ovary (CHO) cells are frequently used to produce recombinant HIV envelope protein gp120. In this study, we characterized the CHO proteins that become co-purified with gp120 when lectin affinity chromatography is used. Many of co-purified CHO proteins identified were extracellular m...
ORGANISM(S): Cricetulus Griseus (ncbitaxon:10029) 
2018-01-25 | MSV000081974 | MassIVE
ProteomicsChinese Hamster Ovary cell proteins co-purified with recombinant HIV-1 envelopes, part 4
Chinese Hamster Ovary (CHO) cells are frequently used to produce recombinant HIV envelope protein gp120. In this study, we characterized the CHO proteins that become co-purified with gp120 when lectin affinity chromatography is used. Many of co-purified CHO proteins identified were extracellular m...
ORGANISM(S): Cricetulus Griseus (ncbitaxon:10029) 
2018-01-25 | MSV000081976 | MassIVE
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