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TranscriptomicsDecreased expression of key tumour suppressor microRNAs is associated with lymph node metastases in triple negative breast cancer
Breast cancer is the most common malignancy that develops in women, responsible for the highest cancer-associated death rates. Triple negative breast cancers (TNBC) represent an important subtype that have an aggressive clinical phenotype, are associated with a higher likelihood of metastasis and ar...
ORGANISM(S): Homo sapiens 
2014-11-24 | E-GEOD-38167 | biostudies-arrayexpress
TranscriptomicsscRNA-seq of lymph node of mice where Cip2a locus has been disrupted and wild-type control mice at the peak of Experimental Autoimmune Encephalomyelis
We induced EAE in mice carrying a gene-trap disruption of Cip2a (hereafter referred to as knockout [KO] mice) and wild-type (WT) control C57BL/6J male and female mice, aged 8-12 weeks. We performed scRNA-seq analysis of lymph node cells from five WT and five KO mice at the peak of EAE. The goal was ...
ORGANISM(S): Mus musculus 
2026-09-30 | E-MTAB-17644 | biostudies-arrayexpress
TranscriptomicsImmune and tumor cell gene expression from node positive and node negative breast cancers' primary tumor, lymph nodes and peripheral blood
Analysis of purified immune and breast tumor cells from three major compartments where cancer and immune cells interact: primary tumor, tumor draining lymph nodes (tumor invaded or tumor free), and peripheral blood. The results suggests that node-positive patients’ immune regulation and functionali...
ORGANISM(S): Homo sapiens 
2013-01-11 | E-GEOD-41986 | biostudies-arrayexpress
TranscriptomicsTranscriptomic survey of lymph node-positive vs. - negative ductal breast cancer
Lymph node involvement is a major prognostic variable in breast cancer. Whether the molecular mechanisms that drive breast cancer cells to colonize lymph nodes are shared with their capacity to form distant metastases is yet to be established. In a transcriptomic survey aimed at identifying molecula...
ORGANISM(S): Homo sapiens 
2013-03-05 | E-GEOD-44408 | biostudies-arrayexpress
MetabolomicsSimultaneous targeting of PD-1 and IL2Rβγ with radiation therapy to inhibit pancreatic cancer growth and metastasis - mouse spleen and lymph node T-cell metabolomics
Not available
ORGANISM(S): Mus musculus 
ST002487 | MetabolomicsWorkbench
ProteomicsSera Protein Signatures of Endometrial Cancer Lymph Node Metastases
sera collected from endometrial cancer patients submitted to direct MS/MS analysis in diluted unprocessed form. MS only analysis of sera has also been performed. files are also available.
ORGANISM(S): Homo Sapiens (human) 
2022-03-17 | PXD031892 | JPOST Repository
TranscriptomicsPrediction of lymph node involvement in breast cancer from primary tumor tissue using gene expression profiling and miRNAs.
Lymph node involvement is the most important prognostic factor in breast cancer, but little is known about the underlying molecular changes. First, to identify a molecular signature associated with nodal metastasis, gene expression analysis was performed on a homogeneous group of 96 primary breast t...
ORGANISM(S): Homo sapiens 
2011-02-04 | E-GEOD-23177 | biostudies-arrayexpress
ProteomicsiTRAQ proteomics of sentinel lymph nodes for the identification of extra cellular matrix protein signatures that can flag metastasis in early breast cancer
Background Breast cancer patients who present in the early stage of disease are affected by metastasis to the axillary group of lymph nodes. The first among this group that is affected is called as sentinel lymph node, and metastasis to this lymph node is crucial for the staging of cancer and the qu...
ORGANISM(S): Homo sapiens (Human) 
2022-05-01 | PXD027668 | Pride
Itraq proteomics Extracellular matrix proteins Early breast cancer Sentinel lymph node metastasis 
TranscriptomicsMicroarray analyses of lymph node dendritic cells (DCs) stimulated in vitro with papain or LPS
T helper type 2 (Th2) responses are induced by protease allergens and helminthes. However the molecular mechanisms that initiate Th2 responses are poorly understood. To obtain insight into this mechanism, we performed a microarray analysis of lymph node DCs stimulated in vitro with the protease alle...
ORGANISM(S): Mus musculus 
2010-05-05 | E-GEOD-21602 | biostudies-arrayexpress
TranscriptomicsGene expression in the pancreatic lymph node of Deaf1 knock out mice vs. BALB/c controls
A microarray study performed in the pancreatic lymph nodes of Deaf1 knock-out and BALB/c control mice to identify genes that are regulated by the transcriptional regulator Deaf1. These experiments constitute a portion of the study described below: Abstract: Type 1diabetes (T1D) can result from a b...
ORGANISM(S): Mus musculus 
2010-04-08 | E-GEOD-13163 | biostudies-arrayexpress
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