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TranscriptomicsTranscriptome of LYN deficient HS-5 stroma cells
LYN kinase is a tyrosine kinase, that regulates cellular homeostasis in a context-specific manner. Our group could show, that its expression in the leukemic microenvironment of chronic lymphocytic leukemia contributes to disease progression (Nguyen PH et al.; Cancer Cell; 2016). To analyze the effec...
ORGANISM(S): Homo sapiens 
2023-01-01 | E-MTAB-10980 | biostudies-arrayexpress
TranscriptomicsRNA-Seq analysis of LYN deficient HS-5 stroma cells cocultured with primary human CLL cells
LYN kinase is a tyrosine kinase, that regulates cellular homeostasis in a context-specific manner. Our group could show, that its expression in the leukemic microenvironment of chronic lymphocytic leukemia contributes to disease progression (Nguyen PH et al.; Cancer Cell; 2016). To analyze the effec...
ORGANISM(S): Homo sapiens 
2023-02-10 | E-MTAB-12629 | biostudies-arrayexpress
TranscriptomicsRNA-Seq analysis of LYN deficient stromal cells sorted from murine spleens
LYN kinase is a tyrosine kinase, that regulates cellular homeostasis in a context-specific manner. Our group could show, that its expression in the leukemic microenvironment of chronic lymphocytic leukemia contributes to disease progression (Nguyen PH et al.; Cancer Cell; 2016). We analyzed the eff...
ORGANISM(S): Mus musculus 
2023-02-10 | E-MTAB-12630 | biostudies-arrayexpress
TranscriptomicsPrognostic signature of epithelial-mesenchymal transition in breast cancer
Epithelial-mesenchymal transition (EMT), a switch of polarized epithelial cells to a migratory, fibroblastoid phenotype, is considered a key process driving tumor cell invasiveness and metastasis. Using breast cancer cell lines as a model system, we sought to discover gene-expression signatures of ...
ORGANISM(S): Homo sapiens 
2010-04-11 | E-GEOD-13915 | biostudies-arrayexpress
ProteomicsTyrosine Phosphorylation of NLRP3 by Src Family Protein Tyrosine Kinase Lyn Suppresses NLRP3 Inflammasome Activation
The NLRP3 inflammasome is a multi-protein complex that triggers the activation of the inflammatory protein caspase-1 and the maturation of the cytokine IL-1 in response to microbes and other danger signals in host cells. Here, we sought a deeper understanding of how the NLRP3 inflammasome is regulat...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-19 | PXD028582 | Pride
Lyn tryosine kinase Murine nlrp3 inflammasome 
ProteomicsSecretome of LYN deficient HS-5 stroma cells
LYN kinase is a tyrosine kinase, that regulates cellular homeostasis in a context specific manner. Our group could show, that its expression in the leukemic microenvironment of chronic lymphocytic leukemia contributes to disease progression (Nguyen PH et al.; Cancer Cell; 2016). To analyze the effec...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD028855 | Pride
Lyn kinase Hs-5 Stroma Bmsc Secretome Multi-omics 
GenomicsMacrophage Lyn kinase is a Sex-Specific Regulator of Post-SAH Neuroinflammation
Macrophage Lyn kinase is a Sex-Specific Regulator of Post-SAH Neuroinflammation
PRJNA1213855 | ENA
ProteomicsProteome / pYome of LYN deficient HS-5 stroma cells
LYN kinase is a tyrosine kinase, that regulates cellular homeostasis in a context specific manner. Our group could show, that its expression in the leukemic microenvironment of chronic lymphocytic leukemia contributes to disease progression (Nguyen PH et al.; Cancer Cell; 2016). To analyze the effec...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD030582 | Pride
Lyn kinase Hs-5 Stroma Bmsc Secretome Multi-omics 
TranscriptomicsATAC-Seq analysis of LYN deficient HS-5 stroma cells
LYN kinase is a tyrosine kinase, that regulates cellular homeostasis in a context-specific manner. Our group could show, that its expression in the leukemic microenvironment of chronic lymphocytic leukemia contributes to disease progression (Nguyen PH et al.; Cancer Cell; 2016). To analyze the effec...
ORGANISM(S): Homo sapiens 
2024-01-01 | E-MTAB-12531 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in wild-type, Irf5-KO, Lyn-KO and Lyn/Irf5-DKO BMDCs unstimulated or stimulated with CpG-B ODN
To characterize the relationship between IRF5 and Lyn in innate immune responses at a genome-wide scale, we performed gene expression microarray analysis for wild-type (WT), Irf5-KO, Lyn-KO and Lyn/Irf5-DKO bone marrow-derived dendritic cells (BMDCs) with or without 6 h-stimulation with 150 nM CpG-B...
ORGANISM(S): Mus musculus 
2016-07-25 | E-GEOD-63014 | biostudies-arrayexpress
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