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TranscriptomicsTranscriptomic analysis of the stress response to weaning at housing in bovine leukocytes using RNA-seq technology
Background: Weaning of beef calves is a necessary husbandry practice and involves separating the calf from its mother, resulting in numerous stressful events including dietary change, social reorganisation and the cessation of the maternal-offspring bond and is often accompanied by housing. While mu...
ORGANISM(S): Bos taurus 
2012-06-25 | E-GEOD-37447 | biostudies-arrayexpress
TranscriptomicsA next generation sequencing approach to profiling the host miRNA response to a bovine mastitis pathogen
Substantial evidence is now beginning to emerge that miRNAs, short, non-coding RNAs, which post-transcriptionally regulate gene expression, play a key role in the regulation of innate and adaptive immunity in humans and mice. Little is currently known, however, regarding the importance miRNAs in reg...
ORGANISM(S): Bos taurus 
2013-10-02 | E-GEOD-41278 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression of bovine monocyte-derived macrophages in response to in vitro challenge with Mycobacterium bovis
Background: Mycobacterium bovis, the causative agent of bovine tuberculosis, is a major cause of mortality in global cattle populations. Macrophages are among the first cells types to encounter M. bovis following exposure and the response elicited by these cells is pivotal in determining the outcome...
ORGANISM(S): Bos taurus 
2011-12-31 | E-GEOD-33309 | biostudies-arrayexpress
UnknownAddition of Vincristine and Irinotecan to Vincristine, Dactinomycin, and Cyclophosphamide Does Not Improve Outcome for Intermediate-Risk Rhabdomyosarcoma: A Report From the Children's Oncology Group.
Not available
S-EPMC6145831 | biostudies-literature
TranscriptomicsRNA-seq analysis of differential gene expression in liver from lactating dairy cows divergent in negative energy balance
Background: The liver is central to most economically important metabolic processes in cattle. However, the changes in expression of genes that drive these processes remain incompletely characterised. RNA-seq is the new gold standard for whole transcriptome analysis but so far there are no reports o...
ORGANISM(S): Bos taurus 
2012-04-25 | E-GEOD-37544 | biostudies-arrayexpress
TranscriptomicsThe miRNAome of the postpartum dairy cow liver in negative energy balance
Negative energy balance (NEB) is an altered metabolic state in high yielding cows that occurs during the first few weeks postpartum when energy demands for lactation and maintenance exceed the energy supply from dietary intake. NEB can, in turn, lead to metabolic disorders and to reduced fertility. ...
ORGANISM(S): Bos taurus 
2014-03-14 | E-GEOD-55882 | biostudies-arrayexpress
TranscriptomicsDysregulation of Endometrial Inflammation Precedes the Development of Cytological Endometritis [mRNA]
The regulation of endometrial inflammation has important consequences for the resumption of bovine fertility post-partum. All cows experience bacterial influx into the uterus after calving; however a significant proportion fail to clear infection leading to the development of cytological endometriti...
ORGANISM(S): Bos taurus 
2015-08-01 | E-GEOD-66825 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of FACS sorted mouse calvarial osteroblasts at defined differentiation stages to identify genes highly associated with osteoblast differentiation
This study compares a comprehensive microarray analysis of unsorted mCOB cultures at two level of cell differentiation with cells that are more homogeneous for a level of cellular differentiation. It demonstrates the loss of information and in some cases misinformation that occurs when a heterogeneo...
ORGANISM(S): Mus musculus 
2007-08-31 | E-GEOD-2332 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse hematopoietic cells at different differentiation stages: hematopoietic stem cells (HSCs), progenitor cells (HPCs), and granulocytes somatic cells are more efficient than adult stem cells for cloning by somatic cell nuclear transfer
Since the creation of Dolly, the first sheep cloned via somatic cell nuclear transfer (SCNT), in 1997, more than a dozen species of mammals have been cloned using this technology. One hypothesis for the limited success of cloning via SCNT (1-5%) is that the clones are likely derived from adult stem...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-5677 | biostudies-arrayexpress
TranscriptomicsDysregulation of Endometrial Inflammation Precedes the Development of Cytological Endometritis [miRNA]
The regulation of endometrial inflammation has important consequences for the resumption of bovine fertility post-partum. All cows experience bacterial influx into the uterus after calving; however a significant proportion fail to clear infection leading to the development of cytological endometriti...
ORGANISM(S): Bos taurus 
2015-08-01 | E-GEOD-66826 | biostudies-arrayexpress
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