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ProteomicsA Lysosome membrane regeneration pathway depends on TBC1D15 and autophagic lysosomal reformation proteins
Acute lysosomal membrane damage reduces the cellular population of functional lysosomes. However, these damaged lysosomes have a remarkable recovery potential independent of lysosomal biogenesis and remain unaffected in TFEB/TFE3-depleted cells. We combined proximity labelling based proteomics, bioc...
ORGANISM(S): Homo sapiens (Human) 
2023-03-07 | PXD040191 | Pride
Autophagy Lysosomal regeneration Lysosomes Autophagic lysosomal reformation Tbc family of proteins 
UnknownIn vivo monitoring of tissue regeneration using a ratiometric lysosomal AIE probe.
Not available
S-EPMC8157324 | biostudies-literature
UnknownLysosome-Featured Cell Aggregate-Released Extracellular Vesicles Regulate Iron Homeostasis and Alleviate Post-Irradiation Endothelial Ferroptosis for Mandibular Regeneration.
Not available
S-EPMC12442703 | biostudies-literature
UnknownLeucine/glutamine and v-ATPase/lysosomal acidification via mTORC1 activation are required for position-dependent regeneration.
Not available
S-EPMC5974189 | biostudies-literature
UnknownTMEM9-v-ATPase Activates Wnt/β-Catenin Signaling Via APC Lysosomal Degradation for Liver Regeneration and Tumorigenesis.
Not available
S-EPMC7647947 | biostudies-literature
ProteomicsLFQ DIA to analyze the proteome of NPC mutant iNeurons with and without ferric ammonium citrate
Label-free quantification (LFQ) using data-independent acquisition (DIA) on the Orbitrap Astral was performed to analyze the proteome of iNeurons with NPC1 and NPC2 knocked out. The experiment includes the following time points of development: day 0, 4, 8, 16, and 22. All samples were cultured in re...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000095985 | MassIVE
UnknownEndo-lysosomal dysfunction in human proximal tubular epithelial cells deficient for lysosomal cystine transporter cystinosin.
Not available
S-EPMC4374958 | biostudies-literature
UnknownRestoration of lysosomal function after damage is accompanied by recycling of lysosomal membrane proteins.
Not available
S-EPMC7224388 | biostudies-literature
GenomicsInceptor binds to and directs insulin towards lysosomal degradation in beta-cells
Inceptor binds to and directs insulin towards lysosomal degradation in beta-cells
PRJNA939837 | ENA
UnknownInactive ryanodine receptors sustain lysosomal availability for autophagy by promoting ER-lysosomal contact site formation.
Not available
S-EPMC12868791 | biostudies-literature
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