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ProteomicsProteomic analysis links truncated tau to lysosome motility, autophagy and endo-lysosomal dysfunction
Tauopathies are characterized by the progressive accumulation of abnormal tau species, which disrupt the autophagy-lysosomal pathway (ALP), a critical system for degrading intracellular macromolecules and aggregated proteins, causing toxicity and cell death. This study investigates the impact of the...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-22 | PXD062128 | Pride
Tauopathies Toxicity Proteomics Mass spectrometry Autosomal 
GenomicsLoss of Gak leads to lysosome dysfunction and immune modulation in podocytes
Loss of Gak leads to lysosome dysfunction and immune modulation in podocytes
PRJNA1288537 | ENA
TranscriptomicsTranscription profiling of rat penis samples from animals with diabetes-induced erectile dysfunction
Gene expression analysis in control and diabetic rats. Diabetes-induced erectile dysfunction in rat model of DM. 10 weeks of streptozotocin induced diabetes. F344 Rats.
ORGANISM(S): Rattus norvegicus 
2007-10-08 | E-GEOD-2457 | biostudies-arrayexpress
TranscriptomicsLoss of Gak leads to lysosome dysfunction and immune modulation in podocytes
Lysosome impairment causes cellular and organ dysfunction, highlighting its crucial role in homeostasis. In this study, we uncovered the indispensable role of cyclin G-associated kinase (GAK) in maintaining podocyte lysosome integrity. We previously showed that podocyte-specific loss of Gak (Gak-KO)...
ORGANISM(S): Mus musculus 
2026-06-18 | GSE302106 | GEO
ProteomicsLysosome-autophagy dysfunction contribute to TDCIPP induced Aβ1-42 production in N2a-APPswe cells.
Alzheimer's disease is the most common form of dementia characterized on cognitive impairment. Autophagy-lysosome dysfunction is linked to AD pathology. Tris (1,3-dichloro-2-propyl) phosphate (TDCIPP) is a widely used organophosphorus flame retardants with the potential to induce neuronal damage. We...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-24 | PXD042789 | Pride
Abeta42  stat1  alzheimer disease autophagy 
UnknownMacrophage Raptor Deficiency-Induced Lysosome Dysfunction Exacerbates Nonalcoholic Steatohepatitis.
Not available
S-EPMC6282883 | biostudies-literature
UnknownLysosome dysfunction as a cause of neurodegenerative diseases: Lessons from frontotemporal dementia and amyotrophic lateral sclerosis.
Not available
S-EPMC8113138 | biostudies-literature
UnknownTriggering role of acid sphingomyelinase in endothelial lysosome-membrane fusion and dysfunction in coronary arteries.
Not available
S-EPMC2838547 | biostudies-literature
GenomicsCRISPR knockout screen implicates three genes in lysosome function
CRISPR knockout screen implicates three genes in lysosome function
PRJNA530740 | ENA
Genomicsβ2-adrenergic agonists rescue lysosome acidification and function in PSEN1 deficiency by reversing defective ER to lysosome delivery of ClC-7
β2-adrenergic agonists rescue lysosome acidification and function in PSEN1 deficiency by reversing defective ER to lysosome delivery of ClC-7
PRJNA564002 | ENA
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