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ProteomicsLysosomal proteomics by affinity purification-mass spectrometry
The aims of this project is to establish a comprehensive proteomic map of the lysosomes using isolated lysosomes via affinity purification. Affinity-purified mitochondria was used as a control to demonstrate the organelle specificity. In this study, we identified several lipid transporters that are ...
ORGANISM(S): Homo sapiens (Human) 
2019-09-27 | PXD014733 | Pride
Mtorc1 Organelle Lysosome immunoprecipitation 
ProteomicsQuantitative Phosphoproteomic Analyses Identify STK11IP as a Lysosome-Specific Substrate of mTORC1 that Regulates Lysosomal Acidification
The evolutionarily conserved serine/threonine kinase mTORC1 is a central regulator of cell growth and proliferation. mTORC1 is activated on the lysosome surface. However, once mTORC1 is activated, it is unclear whether mTORC1 phosphorylates local lysosomal proteins to regulate specific aspects of ly...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD031543 | Pride
Phosphoproteomics stk11ip 
ProteomicsCharacterization of a novel membrane complex required for docking and regulated exocytosis of lysosome-related organelles in Tetrahymena thermophila
In the ciliate Tetrahymena thermophila, lysosome-related organelles called mucocysts accumulate at the cell periphery where they secrete their contents in response to extracellular events, a phenomenon termed regulated exocytosis. A forward genetic approach uncovered MDL1 (Mucocyst Discharge with a ...
ORGANISM(S): Tetrahymena thermophila CU428 
2022-04-06 | PXD028372 | Pride
Exocytosis Mucocysts Ciliate Tetrahymena Lysosome Mdl1 
GenomicsATAD3A Limits Aortic Dissection via Mito-Lysosome Contacts and Lipoylation
ATAD3A Limits Aortic Dissection via Mito-Lysosome Contacts and Lipoylation
PRJNA1458662 | ENA
UnknownThe HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17.
Not available
S-EPMC3982997 | biostudies-literature
UnknownAsparagine endopeptidase regulates lysosome homeostasis via modulating endomembrane phosphoinositide composition.
Not available
S-EPMC11693757 | biostudies-literature
ProteomicsProteomics analysis of lysosomes and whole cell lysates from H4 cellsLysosome, H4, glucocerebrosidase
Studies have shown that the majority of Parkinson's disease patients have at least one putative damaging variant in a lysosomal storage disorder gene (60%) and in about 10% of sporadic PD subjects, the disease is associated with mutations in GBA1, a gene coding for glucocerebrosidase, a lysosomal hy...
ORGANISM(S): Homo sapiens (Human) 
2023-03-24 | PXD036361 | Pride
Lysosome Glucocerebrosidase H4 
UnknownDownregulation of MYO1C mediated by cepharanthine inhibits autophagosome-lysosome fusion through blockade of the F-actin network.
Not available
S-EPMC6836678 | biostudies-literature
UnknownProtocol for qualitative analysis of lysosome immunoprecipitation from patient-derived glioblastoma stem-like cells.
Not available
S-EPMC11215108 | biostudies-literature
UnknownThe identification of high-performing antibodies for transmembrane protein 106B (TMEM106B) for use in Western blot, immunoprecipitation, and immunofluorescence.
Not available
S-EPMC10403746 | biostudies-literature
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