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ProteomicsIdentification of protein substrates of a novel proteolysis targeting chimera, PROTAC124 in tongue squamous cell carcinoma cell line CAL-33 overexpressing Leucine Zipper-bearing Kinase (LZK).
Head and neck squamous cell carcinomas (HNSCC) are aggressive epithelial tumors with a low and unchanged 50% 5-year survival rate. MAP3K13 gene encoding Leucine Zipper-bearing Kinase (LZK) is often amplified in HNSCC patients and can be an oncogenic driver for tumorigenesis. In order to reduce catal...
ORGANISM(S): Homo sapiens (Human) 
2025-06-16 | PXD057778 | Pride
Map3k13) Head and neck cancer Targeted protein degradation Protac (proteolysis targeting chimera) Hnscc Leucine zipper-bearing kinase (lzk 
GenomicsClostridium butyricum strain:LZK-08
Clostridium butyricum strain:LZK-08 Genome sequencing
PRJNA1259948 | ENA
ProteomicsNovel proteolysis targeting chimera (PROTAC) selectively targeting Leucine Zipper-bearing Kinase (LZK) limits oncogenic potential of head and neck cancers.
Head and neck squamous cell carcinomas (HNSCC) are aggressive epithelial tumors with a low and unchanged 50% 5-year survival rate. MAP3K13 gene encoding Leucine Zipper-bearing Kinase (LZK) is often amplified in HNSCC patients and can be an oncogenic driver for tumorigenesis. In order to reduce catal...
ORGANISM(S): Homo sapiens (Human) 
2026-02-16 | PXD054481 | Pride
Leucine zipper-bearing kinase Lzk Head and neck cancer Targeted protein degradation Protac Map3k13 Proteolysis targeting chimera Hnscc 
GenomicsLactococcus lactis subsp. lactis strain:LZK-02
Lactococcus lactis subsp. lactis strain:LZK-02 Genome sequencing
PRJNA1260134 | ENA
UnknownLZK-dependent stimulation of astrocyte reactivity promotes corticospinal axon sprouting.
Not available
S-EPMC9520579 | biostudies-literature
UnknownTargeting GOF p53 and c-MYC through LZK Inhibition or Degradation Suppresses Head and Neck Tumor Growth.
Not available
S-EPMC11601640 | biostudies-literature
UnknownDiscovery of potent and selective PROTACs for the protein kinase LZK for the treatment of head and neck cancer.
Not available
S-EPMC12135360 | biostudies-literature
UnknownThe MAP3Ks DLK and LZK Direct Diverse Responses to Axon Damage in Zebrafish Peripheral Neurons.
Not available
S-EPMC9374156 | biostudies-literature
UnknownActivation of MAP3K DLK and LZK in Purkinje cells causes rapid and slow degeneration depending on signaling strength.
Not available
S-EPMC7870138 | biostudies-literature
TranscriptomicsConsequences of reactive astrogliosis in vivo III
To investigate the role of LZK kinase activity in the astrocyte transcriptome, we locally injected AAV2/5 GfaABC1D-Myc-LZK, the kinase-dead mutant AAV2/5 GfaABC1D-Myc-LZK (K195A), or the viral baseline control AAV2/5 GfaABC1D-tdTomato into the dorsal striatum of C57BL/6NTac mice. AAV2/5 GfaABC1D-Rib...
ORGANISM(S): Mus musculus 
2026-09-23 | GSE336013 | GEO
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