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UnknownThe MAP3K13-TRIM25-FBXW7α axis affects c-Myc protein stability and tumor development.
Not available
S-EPMC7205897 | biostudies-literature
UnknownmicroRNA-206 impairs c-Myc-driven cancer in a synthetic lethal manner by directly inhibiting MAP3K13.
Not available
S-EPMC4941324 | biostudies-literature
Unknownlnc-MAP3K13-7:1 Inhibits Ovarian GC Proliferation in PCOS via DNMT1 Downregulation-Mediated CDKN1A Promoter Hypomethylation.
Not available
S-EPMC7934583 | biostudies-literature
UnknownLINC01287 facilitates proliferation, migration, invasion and EMT of colon cancer cells via miR-4500/MAP3K13 pathway.
Not available
S-EPMC8259379 | biostudies-literature
ProteomicsIdentification of protein substrates of a novel proteolysis targeting chimera, PROTAC124 in tongue squamous cell carcinoma cell line CAL-33 overexpressing Leucine Zipper-bearing Kinase (LZK).
Head and neck squamous cell carcinomas (HNSCC) are aggressive epithelial tumors with a low and unchanged 50% 5-year survival rate. MAP3K13 gene encoding Leucine Zipper-bearing Kinase (LZK) is often amplified in HNSCC patients and can be an oncogenic driver for tumorigenesis. In order to reduce catal...
ORGANISM(S): Homo sapiens (Human) 
2025-06-16 | PXD057778 | Pride
Map3k13) Head and neck cancer Targeted protein degradation Protac (proteolysis targeting chimera) Hnscc Leucine zipper-bearing kinase (lzk 
ProteomicsNovel proteolysis targeting chimera (PROTAC) selectively targeting Leucine Zipper-bearing Kinase (LZK) limits oncogenic potential of head and neck cancers.
Head and neck squamous cell carcinomas (HNSCC) are aggressive epithelial tumors with a low and unchanged 50% 5-year survival rate. MAP3K13 gene encoding Leucine Zipper-bearing Kinase (LZK) is often amplified in HNSCC patients and can be an oncogenic driver for tumorigenesis. In order to reduce catal...
ORGANISM(S): Homo sapiens (Human) 
2026-02-16 | PXD054481 | Pride
Leucine zipper-bearing kinase Lzk Head and neck cancer Targeted protein degradation Protac Map3k13 Proteolysis targeting chimera Hnscc 
UnknownClinical significance of mitogen-activated protein kinase kinase kinases in hepatitis B virus -related hepatocellular carcinoma and underlying mechanism exploration.
Not available
S-EPMC9278978 | biostudies-literature
UnknownTargeting GOF p53 and c-MYC through LZK Inhibition or Degradation Suppresses Head and Neck Tumor Growth.
Not available
S-EPMC11601640 | biostudies-literature
UnknownMAP3K13-232aa encoded by circMAP3K13 enhances cisplatin-induced pyroptosis by directly binding to IKKα in gastric adenocarcinoma
Not available
S-EPMC12402440 | biostudies-literature
TranscriptomicsA study of alterations in DNA epigenetic modifications (5mC and 5hmC) and gene expression influenced by simulated microgravity in human lymphoblastoid cells [RNA-seq]
Here, in this study we systematically examined the patterns of DNA methylation and hydroxy-methylation with its functional implications in gene regulation for the cultured TK6 lymphoblastoid cells upon exposure to micro-gravity conditions. The results reported here indicate that simulated microgravi...
ORGANISM(S): Homo sapiens 
2016-02-02 | GSE65943 | GEO
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