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MetabolomicsMetabolic alterations in immune cells associate with progression to type 1 diabetes

AIMS: Previous metabolomics studies suggest that type 1 diabetes is preceded by specific metabolic disturbances. The aim of this study was to investigate whether distinct metabolic patterns occur in peripheral blood mononuclear cells (PBMCs) of children who later develop pancreat...

2020-08-10 | MTBLS1015 | MetaboLights
MetabolomicsAdvancing Reef Monitoring Techniques through Exometabolomics: Quantification of Labile Dissolved Organic Metabolites on Coral Reefs

Extracellular chemical cues constitute much of the language of life among marine organisms from microbes to mammals. These chemical cues shape foraging and feeding strategies, symbiotic interactions, selection of mates and habitats, and the transfer of energy and nutrient...

2025-07-16 | MTBLS9008 | MetaboLights
ProteomicsLFQ proteomics of Streptomyces albus phosoablative CslA mutant strain
Aim of this study was to compare proteomic profiles of the WT and the pMD8 mutant strains of Streptomyces albus. pMD8 is a mutant encoding a phosphoablative form of the CslA gene (T17A). Study is a part of a bigger project on the roles of PknB and CslA proteins in cell wall morphogenesis of Streptom...
ORGANISM(S): Streptomyces albus J1074 
2026-06-17 | PXD071342 | Pride
Hdmse Tip organising centre (tipoc) Cell morphogenesis Roda Csla Lfq Phosphorylation Streptomyces Pknb Polarisome Cell wall Bottom-up 
ProteomicsBottom-up proteomics of EA-cells expressing HyPer7
Untargeted bottom-up whole proteome analysis of EA-cells expressing cytosolic HyPer7 biosensor using ACQUITY UPLC M-Class, coupled to a SYNAPT G2-Si MS
ORGANISM(S): Homo Sapiens (human) 
2024-11-02 | PXD056727 | JPOST Repository
ProteomicsImpact of Oxygen Tension on the Proteomic Profile of hCMEC/D3 Cells and Implications for Drug Screening
Untargeted bottom-up proteomic analysis of hCMEC/D3 cells, cultured at 5 kPa and 18 kPa O₂, in the presence and absence of sulforaphane treatment, using an ACQUITY UPLC M-Class system coupled to a SYNAPT G2-Si mass spectrometer.
ORGANISM(S): Homo Sapiens (human) 
2025-04-12 | PXD060622 | JPOST Repository
ProteomicsImpact of Variation in CYP3A and CYP2C8 on Tucatinib Metabolic Clearance in Human Liver Microsomes
Tucatinib is a tyrosine kinase inhibitor (TKI) indicated for HER2 positive breast cancer. It is metabolized primarily by cytochrome P450 (CYP) 2C8 and CYP3A. Given the interindividual variability in the pharmacokinetics of some TKIs, this study explored how variability in CYP2C8 and CYP3A activities...
ORGANISM(S): Homo sapiens (Human) 
2025-04-17 | PXD057282 | Pride
Quantitative proteomics M-class acquity Kinase inhibitor Triple quadrupole 7500 
ProteomicsMechanism of chaperone coordination during cotranslational protein folding in bacteria
Protein folding is assisted by molecular chaperones that bind nascent polypeptides during mRNA translation. Several structurally-distinct classes of chaperones promote de novo folding, suggesting that their activity is coordinated at the ribosome. Here we use biochemical reconstitution and structura...
ORGANISM(S): Escherichia coli 
2024-07-03 | PXD048638 | Pride
Nascent chain Ribosomes Hdx-ms Molecular chaperones Protein synthesis Β-galactosidase Protein folding 
ProteomicsIdentification of dystrophin Dp71dΔ71 associated proteins in PC12 cells by quantitative proteomics
Dystrophin Dp71 is the main product of the DMD (Duchenne muscular dystrophy) gene in the brain. Dystrophin Dp71 is essential for the development of the nervous system and its alteration is associated with intellectual disability. Different isoforms of Dp71, with different subcellular locations, are ...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-11-01 | PXD021886 | Pride
Quantitative proteomics. Dp71 Protein interaction Dmd 
ProteomicsExpression profiles of kidney mitochondrial proteome during the progression of the unilateral ureteral obstruction: focus on energy metabolism adaptions.
Obstructive nephropathy (ON) is a common clinical entity caused by different etiologies such as urolithiasis, prostatic hyperplasia in males, tumors, congenital stenosis, and others. Unilateral ureteral obstruction (UUO) in rodents is an experimental model widely used to explore the pathophysiology ...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-10-18 | PXD036205 | Pride
Kidney fibrosis Mitochondria proteome Energy metabolism. Unilateral ureteral obstruction (uuo) 
ProteomicsProteomic characterization of the pellicle of Toxoplasma gondii
Toxoplasma gondii is an obligate intracellular parasite. The ability to invade cells and proliferate successfully is given by the machinery found in the pellicle of the parasite, the pellicle is a complex of three membranes. Despite the importance of the pellicle in the biology of Toxoplasma, its pr...
ORGANISM(S): Toxoplasma gondii 
2021-02-16 | PXD022398 | Pride
Toxoplasma Mass spectrometry Protein quantification Adhesion Srs Pellicle 
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