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TranscriptomicsXenopus M-phase extract treated induced pluripotent stem cells
Transfer of somatic cell nuclei to enucleated eggs or ectopic expression of specific transcription factors are two different reprogramming strategies used to generate pluripotent cells from differentiated cells. However, they are poorly efficient and other unknown factors might be required to increa...
ORGANISM(S): Mus musculus 
2011-11-21 | E-GEOD-31691 | biostudies-arrayexpress
GenomicsTranscription factor binding in human cells occurs in dense clusters formed around cohesin anchor sites [S-phase/M-phase synchronized cells]
During cell division, transcription factors (TFs) are removed from chromatin twice, during DNA synthesis, and during condensation of chromosomes. How TFs can efficiently find their sites following these stages has been unclear. Here, we have analyzed the binding pattern of expressed TFs in human col...
ORGANISM(S): Homo sapiens 
2013-10-01 | E-GEOD-51290 | biostudies-arrayexpress
ModelsNovak1993 - Cell cycle M-phase control
Novak1993 - Cell cycle M-phase control The model reproduces Figure 9 of the paper. Please note that active MPF and cyclin concentrations in the paper are given relative to total cdc2 concentration (100nM). Active MPF (dimer_p) is the cyclin-cdc2 complex that is phosphorylated at Thr161. The earl...
2024-09-02 | BIOMD0000000107 | BioModels
TranscriptomicsDistribution of Arp4 in G2/M phase
The actin-related proteins (ARPs) comprise a conserved protein family. Arp4p is found in large multisubunits of the INO80 and SWR1 chromatin remodeling complexes and in the NuA4 histone acetyltransferase complex. Here we show that arp4 (arp4S23AD159A) temperature-sensitive cells are defective in G2/...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-11 | E-GEOD-7276 | biostudies-arrayexpress
TranscriptomicsGlobal analysis of differential polyadenylation of mRNAs during mitotic cell cycle: S phase versus G2/M phase.
We compared the poly(A) tail length status of mRNAs of HeLa cells between two phases of the mitotic cell cycle: S and G2/M phases. Hundreds of mRNAs were found to be regulated by changes in their poly(A) tail length during mitotic cell cycle in a phase specific manner. Many of these differentially p...
ORGANISM(S): Homo sapiens 
2010-05-07 | E-GEOD-15399 | biostudies-arrayexpress
ProteomicsThe M-phase regulatory phosphatase PP2A-B55δ opposes protein kinase A on Arpp19 to initiate meiotic division
Oocytes are held in meiotic prophase for prolonged periods until hormonal signals trigger meiotic divisions. Key players of M-phase entry are the opposing Cdk1 kinase and PP2AB55δ phosphatase. In Xenopus, the protein Arpp19, phosphorylated at serine 67 by Greatwall, plays an essential role in inhibi...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2021-03-12 | PXD022739 | Pride
M-phase Meiotic Xenopus Oocyte Pp2a Phosphatase Phosphorylation B55 Arpp19 
ProteomicsIdentification of CDK1 substrates in mitosis by quantitative phosphoproteomics
Cyclin-dependent kinase 1 (Cdk1) is an essential regulator of many mitotic processes including the reorganization of the cytoskeleton, chromosome segregation, and formation and separation of daughter cells. Deregulation of Cdk1 activity results in defects in these processes. Although the role of Cdk...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-02-24 | MSV000079528 | MassIVE
TranscriptomicsOverexpression of NtmybA2 in tobacco BY-2 cells
Promoters of many G2/M phase-specific genes in plants contain mitosis-specific activator (MSA) elements, which act as G2/M phase-specific enhancers and bind with R1R2R3-Myb transcription factors. A least three R1R2R3-Myb proteins are expressed in tobacco (Nicotiana tabacum). To examine the genome-wi...
ORGANISM(S): Nicotiana tabacum 
2010-05-22 | E-GEOD-14251 | biostudies-arrayexpress
ProteomicsCo-immunoprecipitation of HMMR from M-phase HeLa cells
Co-immunoprecipitation of HMMR from M-phase HeLa cells to discover mitotic mechanisms related to cell cortex stability
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-02-18 | MSV000088870 | MassIVE
GenomicsCheckpoint inhibition of origin firing prevents inappropriate replication in G2/M phase.
Checkpoint inhibition of origin firing prevents inappropriate replication in G2/M phase.
PRJNA686785 | ENA
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