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MetabolomicsComparative metabolomics of Mycoplasma bovis and Mycoplasma gallisepticum reveals fundamental differences in active metabolic pathways and suggests novel gene annotations
Mycoplasmas are simple, but successful parasites that have the smallest genome of any free-living cell and are thought to have a highly streamlined cellular metabolism. Here we have undertaken a detailed metabolomic analysis of two species, Mycoplasma bovis and Mycoplasma gallisepticum, which cause ...
2017-10-10 | MTBLS535 | MetaboLights
MetabolomicsIntegrated Transcriptomic and Metabolomic Analyses Reveal the Antibacterial Mechanism of Isocorydine against Mycobacterium bovis

Mycobacterium bovis, the causative agent of bovine tuberculosis, poses a significant zoonotic threat. This study defines the antibacterial activity and mechanism of the natural alkaloid isocorydine (ICD) against M. bovis using an integrated multi-omics approach. Phenotypic analyses demonstrated t...

2025-12-03 | MTBLS13441 | MetaboLights
TranscriptomicsMycobacterium bovis-BCG vaccination induces a specific pulmonary transcriptome biosignature in mice
In the present study, we applied microarray technology to define a biosignature from the whole genome expression in lung and spleen samples after BCG vaccination and M. bovis infection of BALB/c mice. The aims were two-fold, namely to define biosignatures that could predict vaccine success before ch...
ORGANISM(S): Mus musculus 
2010-07-29 | E-GEOD-21149 | biostudies-arrayexpress
ProteomicsProteomic characterization of the culture supernatant of Mycobacterium bovis in different growth stages
The goal of this study is to identify the different proteins secreted by Mycobacterium bovis in the culture media at different stages of bacterial growth. A field strain of M. bovis was allowed to grow in a culture media and culture supernatant was collected at three-time points representing approxi...
ORGANISM(S): Bacteria Mycobacterium bovis 
2021-12-30 | PXD017817 | Pride
Culture supernatant Secreted proteins M. bovis Growth stage 
TranscriptomicsInflammatory and immune responses in lymph nodes of Iberian red deer infected with Mycobacterium bovis.
Bovine tuberculosis (bTB), caused by Mycobacterium bovis (Mycobacterium tuberculosis complex), is a zoonotic disease that affects cattle and wildlife worldwide. In some regions of Spain, Iberian red deer (Cervus elaphus hispanicus) can serve as reservoir of infection, thus increasing the risk of hum...
ORGANISM(S): Cervus elaphus hispanicus 
2007-10-17 | E-GEOD-6083 | biostudies-arrayexpress
ProteomicsProteomic analysis of protein purified derivative of Mycobacterium bovis
Tuberculin Skin Test (TST) based on in vivo intradermal inoculation of purified protein derivative from M. bovis (bPPD) is the diagnostic test for the control and surveillance of bovine tuberculosis (bTB). Proteomic analyses were performed on four bPPD samples from Mycobacterium bovis, strain AN5. P...
ORGANISM(S): Mycobacterium bovis AN5 
2017-04-05 | PXD005920 | Pride
Ppd Mass spectrometry Proteomics M. bovis 
TranscriptomicsKey hub and bottleneck genes differentiate the macrophage response to virulent and attenuated Mycobacterium bovis
Mycobacterium bovis is an intracellular pathogen that causes tuberculosis in cattle. Following infection, the pathogen resides and persists inside host macrophages by subverting host immune responses via a diverse range of mechanisms. Here, a high-density bovine microarray platform was used to exami...
ORGANISM(S): Bos taurus 
2014-08-01 | E-GEOD-59774 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Mycobacterium bovis to determine genetic requirements for fast and slow growth in Mycobacteria
Mycobacterium tuberculosis infects a third of the world's population. Primary tuberculosis involving active fast bacterial replication is often followed by asymptomatic latent tuberculosis, which is characterised by slow or non-replicating bacteria. Reactivation of the latent infection involving a s...
ORGANISM(S): Mycobacterium bovis 
2009-04-28 | E-BUGS-83 | biostudies-arrayexpress
TranscriptomicsThree-dimensional low shear culture of Mycobacterium bovis BCG induces biofilm formation and antimicrobial drug tolerance
Mycobacteria naturally grow as corded biofilms in liquid media without detergent. Such detergent-free biofilm phenotypes may reflect the growth pattern of bacilli in tuberculous lung lesions. New strategies are required to treat tuberculosis that is responsible for more deaths each year than any oth...
ORGANISM(S): Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2 
2021-01-29 | E-MTAB-9904 | biostudies-arrayexpress
ProteomicsInflammation markers are associated with small extracellular vesicle protein signatures in cows with Mycoplasma bovisInflammation markers are associated with small extracellular vesicle protein signatures in cows with Mycoplasma bovis
Mycoplasma bovis (M. bovis) manifests as diverse clinical pathologies in cattle that significantly impacts cow health and productivity worldwide. This study investigated small extracellular vesicles (sEV) from M. bovis infected dairy cows to identify protein cargo that may be used as potential diagn...
ORGANISM(S): Bos taurus (Bovine) 
2026-06-08 | PXD076220 | Pride
Proteomics Mycoplasma bovis infection Extracellular vesicle Timstof 
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