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Precise regulation of the duration and extent of inflammation is crucial for balancing pathogen elimination and preventing tissue damage. The mechanisms underlying inflammation resolution are not yet fully understood. Here, we reveal that neutrophils, typically known for their pro-inflammatory role ...
ORGANISM(S): Homo sapiens (Human) 
2026-03-23 | PXD048609 | Pride
Gasdermin D (GSDMD)-mediated macrophage pyroptosis plays a critical role in inflammation and host defense. Plasma membrane perforation elicited by caspase-cleaved GSDMD N-terminal domain (GSDMD-NT) triggers membrane rupture and subsequent pyroptotic cell death, resulting in release of pro-inflammato...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD039133 | Pride
Data from ProteomeXchange, PXD ID: PXD002239. Experiment: HILIC_hcd_seaurchin_UN3, file: HILIC_hcd_seaurchin_UN3_F14.mzml. Published as part of Proteomics. 2015 Jul 29 . From the Abstract: {{i}} Fertilization triggers a dynamic symphony of molecular transformations induced by a rapid rise in intrac...
ORGANISM(S): Strongylocentrotus_purpuratus 
Fertilization triggers a dynamic symphony of molecular transformations induced by a rapid rise in intracellular calcium. Most prominent are surface alterations, metabolic activation, cytoskeletal reorganization, and cell cycle reentry. While the activation process appears to be broadly evolutionaril...
ORGANISM(S): Strongylocentrotus purpuratus (Purple sea urchin) 
2015-08-04 | PXD002239 | Pride
The outbreak of coronavirus disease 2019 (COVID-19) is a global health emergency. Various omics results have been reported for COVID-19, but the molecular hallmarks of COVID-19, especially in those patients without comorbidities, have not been fully investigated. Here we collect blood samples from 2...
2021-10-06 | MTBLS2542 | MetaboLights
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