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MetabolomicsTargeting the SREBP-dependent lipidomic reprogramming by virus infection for broad-spectrum therapeutic intervention
Viruses are obligate intracellular parasites that exploit the host metabolic machineries to meet their extraordinary biosynthetic demands. Integrative transcriptomic and lipidomic profiling confirmed that Middle East respiratory syndrome coronavirus (MERS-CoV) infection reprograms the host lipid met...
2018-11-26 | MTBLS762 | MetaboLights
UnknownResponse to Li and Hopper.
Not available
S-EPMC8008475 | biostudies-literature
MetabolomicsAcupuncture Synergized With Bortezomib Improves Survival of Multiple Myeloma Mice via Decreasing Metabolic Ornithine
Multiple myeloma (MM) is a hematological malignancy worldwide in urgent need for novel therapeutic strategies. Since Velcade (bortezomib) was approved for the treatment of relapsed/refractory MM in 2003, we have seen considerable improvement in extending MM patient survival. However, most patients a...
2022-02-21 | MTBLS3487 | MetaboLights
ProteomicsActivation of Akt, Nrf2, and NF-κB signal transduction pathways in the liver as a mechanism of survival for torpid Myotis ricketti Bats
Unfolded protein accumulation in the lumen of endoplasmic reticulum (ER) induced by cold exposure is termed UPRER. Some mammals hibernate to overcome cold winter. We investigated whether hibernating bats are under UPRER and activate Akt, Nrf2, and NF-κB signaling pathways that are critical for cell ...
ORGANISM(S): Myotis ricketti 
2020-11-17 | PXD016109 | Pride
Mitochondria Eif2 Akt Hibernation Upr And lc-ms/ms Nf-κb Bats Proteomics Liver 
ProteomicsNidogen 1-enriched extracellular vesicles facilitate extrahepatic metastasis of liver cancer by activating pulmonary lung fibroblasts to secrete tumor necrosis factor receptor 1
In hepatocellular carcinoma (HCC) patients with extrahepatic metastasis, the lung is the most frequent site of metastasis. However, how the lung microenvironment favors disseminated cells remains unclear. Here, it is found that nidogen 1 (NID1) in HCC cell-derived EVs promoted pre-metastatic niche f...
ORGANISM(S): Homo sapiens (Human) 
2020-11-17 | PXD019566 | Pride
Lc-ms/ms Hepatocellular carcinoma Nid1 
MetabolomicsCharacterization of active peptides derived from three leeches and comparison of their anti-thrombotic mechanisms using the tail vein thrombosis model in mice and metabonomics

BACKGROUND AND AIMS: The increasing incidence of cardiovascular diseases has created an urgent need for safe and effective anti-thrombotic agents. Leech, as a traditional Chinese medicine, has the effect of promoting blood circulation and removing blood stasis, but its real mater...

2024-01-18 | MTBLS9306 | MetaboLights
ProteomicsProximity labeling – LC/MS-MS with ERC1-TurboID/atg7-2 Arabidopsis seedlings
Given that ERC1 proteins are enriched on membraneless condensates together with ATG8 proteins prior to autophagosome formation, we hypothesized that ERC1-positive condensates might serve as an assembly site for ATG8 proteins and other adaptors before ATG8 proteins are conjugated onto the phagophore ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2025-10-07 | PXD067354 | Pride
Erc protein family Atg8 Turboid Biomolecular condensation Autophagosome formation 
ProteomicsProteomics Decipher the Molecular Mechanisms of the Herbal Formula Jing Guan Fang in Suppressing Macrophage-Mediated Inflammation.
In this study, we first performed a deep metabolomic profiling of the JGF aqueous extract to create a detailed phytochemical inventory. We then utilized a classic in vitro model of inflammation—lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages—to validate the formula's anti-inflammatory prop...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-14 | PXD066295 | Pride
Proteomics Jgf Inflammation Cytokine storm 
ProteomicsProximity labeling – LC/MS-MS with TurboID-ATG8e/atg2-1 Arabidopsis seedlings
By employing a proximity labeling approach using Arabidopsis ATG8e tagged with TurboID as bait in atg2-1 background, we discovered a protein family of unknown function, consisting of two homologs (AT4G02880 and AT1G03290). Both proteins contain coil-coiled domains that are predicted to be closely re...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2025-10-07 | PXD067352 | Pride
Turboid Vesicle secretion Ap-ms 
MetabolomicsXiaoyukang Capsules Promote Hematoma Absorption and Alleviate Neuronal Apoptosis via the Sema3A/NRP1-PI3K/AKT Signaling Axis in Rats with Intracerebral Hemorrhage

This study aimed to clarify the pharmacodynamic material basis and molecular mechanisms of Xiaoyukang Capsules (XYKC) in facilitating hematoma absorption and alleviating secondary nerve injury after intracerebral hemorrhage (ICH), and to identify its core therapeutic targets. Methods An ICH rat m...

2026-07-12 | MTBLS15015 | MetaboLights
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