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MetabolomicsPseudomonas syringae infectivity correlates to altered transcript and metabolite levels of Arabidopsis Mediator mutants

Rapid metabolic responses to pathogens are essential for plant survival and depend on numerous transcription factors. Mediator is the major transcriptional co-regulator for integration and transmission of signals from transcriptional regulators to RNA polymerase II. Using four Arabidopsis Mediato...

2024-02-19 | MTBLS8105 | MetaboLights
ProteomicsProteomic profiling of cathepsin specificity by FPPS
Identification of protease substrates and determination of their specificities can provide important insights into their function. In the past decade, several proteomic approaches for identification of protease cleavage sites were developed, each relying on various strategies for peptide labelling a...
ORGANISM(S): Homo sapiens (Human) 
2015-02-10 | PXD001553 | Pride
Degradomics Proteases Cathepsins 
ProteomicsIdentification of differentially expressed proteins during the fermentation of Saccharopolyspora erythraea
At selected timepoints during the S erythrea fermentation process, samples of fermentation broth were collected. Proteins in the samples were separated by 2D-PAGE and differentially expressed proteins were identified by LC-MS/MS.
ORGANISM(S): Saccharopolyspora erythraea (Streptomyces erythraeus) 
2016-05-26 | PXD002677 | Pride
Proteomics Saccharopolyspora erythraea Erythromycin 2d-page 
MetabolomicsMetabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS
As metabolic rewiring is crucial for cancer cell proliferation, metabolic phenotyping of patient-derived organoids is desirable to identify drug-induced changes and trace metabolic vulnerabilities of tumor subtypes. We established a novel protocol for metabolomic and lipidomic profiling of colorecta...
2021-10-12 | MTBLS2130 | MetaboLights
UnknownGenetic interactions between a phospholipase A2 and the Rim101 pathway components in S. cerevisiae reveal a role for this pathway in response to changes in membrane composition and shape.
Not available
S-EPMC2872012 | biostudies-literature
MetabolomicsELAPOR1 induces the classical/progenitor subtype and contributes to reduced disease aggressiveness through metabolic reprogramming in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is a heterogeneous disease with distinct molecular subtypes described as classical/progenitor and basal-like/squamous PDAC. We hypothesized that integrative transcriptome and metabolome approaches can identify candidate genes whose inactivation contributes to ...
2024-04-02 | MTBLS9418 | MetaboLights
UnknownTemperature-independent thermal radiation.
Not available
S-EPMC6936496 | biostudies-literature
UnknownDo the Outcomes of Clinical Efficacy Trials Matter in Regulatory Decision-Making for Biosimilars?
Not available
S-EPMC10581956 | biostudies-literature
MetabolomicsComparing Campylobacter jejuni to three other enteric pathogens in OligoMM 12 mice reveals pathogen-specific host and microbiota responses
Campylobacter jejuni, non-typhoidal Salmonella spp., Listeria monocytogenes and enteropathogenic/enterohemorrhagic Escherichia coli (EPEC/EHEC) are leading causes of food-borne illness worldwide. Citrobacter rodentium has been used to model EPEC and EHEC infection ...
2025-02-25 | MTBLS11078 | MetaboLights
UnknownDesigning Bifunctional Electrocatalysts Based on Complex Cobalt-Sulfo-Boride Compound for High-Current-Density Alkaline Water Electrolysis.
Not available
S-EPMC11460019 | biostudies-literature
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