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GenomicsEnhanced Pathogenicity of Th17 cells Generated in the Absence of Transforming Growth Factor-β Signaling: ChIPSeq
CD4+ T cells that selectively produce interleukin (IL)-17, are critical for host defense and autoimmunity. Crucial for T helper17 (Th17) cells in vivo, IL-23 has been thought to be incapable of driving initial differentiation. Rather, IL-6 and transforming growth factor (TGF)-β1 have been argued to ...
ORGANISM(S): Mus musculus 
2010-08-31 | E-GEOD-23681 | biostudies-arrayexpress
TranscriptomicsmiRNA measurements in wildtype and Eri1-deficient Th cells
Natural killer (NK) cells play a critical role in early host defense to infected and transformed cells. Here we show that mice deficient in Eri1, a conserved 3M-bM-^@M-^Y-to-5M-bM-^@M-^Y exoribonuclease that represses RNA interference, have a cell-intrinsic defect in the homeostasis and terminal mat...
ORGANISM(S): Mus musculus 
2012-07-10 | E-GEOD-32126 | biostudies-arrayexpress
UnknownRecombinant multimeric dog allergen prevents airway hyperresponsiveness in a model of asthma marked by vigorous TH 2 and TH 17 cell responses.
Not available
S-EPMC9796107 | biostudies-literature
UnknownGut CD4+ T cell phenotypes are a continuum molded by microbes, not by TH archetypes.
Not available
S-EPMC7839314 | biostudies-literature
UnknownTh-POK regulates mammary gland lactation through mTOR-SREBP pathway.
Not available
S-EPMC5821406 | biostudies-literature
ProteomicsImmunomodulation of T helper cells by tumour microenvironment in oral cancer is associated with rapid membrane-associated Vitamin D signalling pathway
The immune system plays a key role in the protective response against oral cancer, however the tumour microenvironment (TME) is able to impair this anti-cancer response by modulating T helper (Th) responses and promoting an anti-inflammatory environment. Regulatory T cells (Tregs) and Th2 effector c...
ORGANISM(S): Homo sapiens (Human) 
2021-04-29 | PXD023049 | Pride
Immunomodulation Ccr8 Th-like tregs Oral cancer Cancer immunology 
UnknownTernary superconducting hydrides stabilized via Th and Ce elements at mild pressures.
Not available
S-EPMC11197597 | biostudies-literature
ProteomicsDeciphering and predicting CD4+ T cell immunodominance of Influenza virus hemagglutinin
The importance of CD4+ T helper (Th) cells is well appreciated in view of their essential role in the elicitation of antibody and cytotoxic T cell responses. However, the mechanisms that determine the selection of immunodominant epitopes within complex protein antigens remain elusive. Here, we used ...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) Influenza A virus (A/California/07-00002/2009(H1N1)) 
2020-06-29 | PXD018151 | Pride
Peptidomics Influenza Mhc-ii Modc Ebv-b Antigen presentation Human Hemagglutinin 
MetabolomicsPositional Enrichment by Proton Analysis (PEPA): a One-Dimensional 1H-NMR Approach for 13C Stable Isotope Tracer Studies in Metabolomics
A novel metabolomics approach for NMR-based stable isotope tracer studies called PEPA is presented, and its performance validated using human cancer cells. PEPA detects the position of carbon label in isotopically enriched metabolites and quantifies fractional enrichment by indirect determination of...
2017-02-23 | MTBLS247 | MetaboLights
TranscriptomicsmiRNAs in activated mouse CD4 T cells by Bcl-6 overexpression
Compare miRNA expression profiles in mouse CD4 T cells overexpression of Bcl-6 vs empty vector Mouse naïve CD4+ T cells were transduced with a Bcl-6-expressing retrovirus or the control vector and cultured in Th0 condition for 2 days. Cells expressing medium to high levels of GFP were sorted and to...
ORGANISM(S): Mus musculus 
2010-05-15 | E-GEOD-17000 | biostudies-arrayexpress
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