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UnknownA Computational Systems Pharmacology Approach to Investigate Molecular Mechanisms of Herbal Formula Tian-Ma-Gou-Teng-Yin for Treatment of Alzheimer's Disease.
Not available
S-EPMC6028720 | biostudies-literature
ProteomicsIntegrative Network Analysis Reveals USP7 Haploinsufficiency Inhibits E-protein Activity in Pediatric T-lineage Acute Lymphoblastic Leukemia (T-ALL)
USP7, which encodes a deubiquitylating enzyme, is among the most frequently mutated genes in pediatric T-ALL, with somatic heterozygous loss-of-function mutations (haploinsufficiency) predominantly affecting the subgroup that has aberrant TAL1 oncogene activation. Network analysis of >200 T-ALL tran...
ORGANISM(S): Homo sapiens (Human) 
2021-03-16 | PXD023377 | Pride
Tal1 T-all Usp7 
ProteomicsA click-compatible BmTyr platform for biotin-free proximity labeling and subcellular proteome profiling in primary T cells
Proximity labeling has revolutionized the study of dynamic subcellular proteomes by enabling the capture of transient protein interactions within living cells, yet the application of existing platforms to hard-to-transfect primary cells remains challenging. Here, we leverage a bioorthogonal proximit...
ORGANISM(S): Mus Musculus 
2026-05-09 | PXD078205 |
ProteomicsBlocking CXCR4+ CD4+ T cells reprograms Treg-mediated immunosuppression via modulating the Rho-GTPase/NF-κB pathway
Clinical trials have demonstrated that CXCR4 antagonists enhance the efficacy of immunotherapy in cancers by reducing regulatory T (Treg) cells, elucidating how certain mechanisms of CXCR4 in affecting Treg cells are essential for developing immunotherapeutic strategies.
ORGANISM(S): Homo Sapiens 
2024-11-25 | PXD058262 |
TranscriptomicsAcid-inducible genes in Streptococcus mutans: multiple two-component systems involved in acid adaptation
Global transcriptional analysis of acid-inducible genes in Streptococcus mutans: multiple two-component systems involved in acid adaptation pH is a major environmental factor that regulates gene expression in many bacteria. Streptococcus mutans in dental biofilms is regularly exposed to cycles of a...
ORGANISM(S): Streptococcus mutans 
2010-05-22 | E-GEOD-15125 | biostudies-arrayexpress
UnknownGenome-wide association study identified candidate genes for egg production traits in the Longyan Shan-ma duck.
Not available
S-EPMC11298941 | biostudies-literature
UnknownEffects of stocking density on ovarian development and maturation during the rearing period in Shan-ma ducks.
Not available
S-EPMC8968648 | biostudies-literature
TranscriptomicsMouse Marginal Zone B-cell with/without Tfh RNASeq data analysis
Mouse Marginal Zone B-cell with/without Tfh
ORGANISM(S): Mus musculus 
2024-01-24 | E-MTAB-11677 | biostudies-arrayexpress
MetabolomicsSupplementation of Bacillus sp. DU-106 reduces hypercholesterolemia and ameliorates gut dysbiosis in high-fat diet rats

Gut microbiota modulation by a probiotic is a novel therapy for hypercholesterolemia mitigation. This study initially investigated the potential hypocholesterolemic effect of Bacillus sp. DU-106 in hypercholesterolemic rats and explored its potential relation with gut microbiota. Sprague-Dawley r...

2021-04-08 | MTBLS1168 | MetaboLights
UnknownWeak SARS-CoV-2-specific responses of TIGIT-expressing CD8 + T cells in people living with HIV after a third dose of a SARS-CoV-2 inactivated vaccine.
Not available
S-EPMC10752475 | biostudies-literature
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