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ProteomicsComprehensive Absolute Quantification of the Cytosolic Proteome of Bacillus subtilis by Data Independent, Parallel Fragmentation in Liquid Chromatography/Mass Spectrometry (LC/MS)
Absolute protein quantification for cytosolic proteins of B. subtilis growing on a carbon source (condition S) or on an amino acid source (condition CH). Data for 3 biological replicates and 3 technical replicates each for each condition are provided. For data processing and protein identification, ...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2014-08-04 | PXD000154 | Pride
Absolute protein quantification Mse Synapt (waters) Dia B. subtilis 
ProteomicsStaphylococcus aureus isolates from the gut and the blood are ‘separated’ by host barrier integrity
The opportunistic pathogen Staphylococcus aureus is carried asymptomatically by about one-third of the human population. Body sites known to be colonized by S. aureus are the skin, nasopharynx and gut. In particular, the mechanisms that allow S. aureus to pass the gut epithelial barrier and to invad...
ORGANISM(S): Staphylococcus aureus 
2023-03-11 | PXD030971 | Pride
S. aureus  gut colonization  bacteremia  wgs  proteome  barrier 
ProteomicsPathogen-pathogen interactions in the microbiome, a way to soothe virulence?
The rise of multi-drug resistance in bacterial pathogens imposes the need to study these organisms from new angles. A little explored outset is to scrutinize bacterial niche adaptations and interactions among pathogenic and commensal bacteria, because they can provide a better understanding of the f...
ORGANISM(S): Klebsiella oxytoca Bacillus thuringiensis Staphylococcus aureus 
2020-04-22 | PXD017208 | Pride
Transcriptome Co-infection Proteome Staphylococcus aureus Klebsiella oxytoca Galleria mellonella Chronic wound 
ProteomicsThe small proteome of the nitrogen-fixing plant symbiont Sinorhizobium meliloti
The Alphaproteobacterium Sinorhizobium meliloti lives in soil and is capable of fixing molecular nitrogen in symbiosis with legume plants. In this work, the small proteome of S. meliloti strain 2011 was studied to uncover translation of both annotated and novel small open reading frame (sORF)-encode...
ORGANISM(S): Sinorhizobium meliloti 2011 
2023-03-13 | PXD034931 | Pride
Rhizobia Proteomics Proteogenomics Sorf Small proteins Ribosome profiling 
ProteomicsThe secreted proteases Aur, ScpA, SspA and SspB suppress virulence of Staphylococcus aureus USA300 by shaping the extracellular proteome
Surface-located and secreted virulence factors of the Gram-positive bacterial pathogen Staphylococcus aureus are key drivers for infection of the human host. Proteolytic enzymes may contribute to virulence by breaking primary barriers and host immune defenses. Therefore, the objective of our present...
ORGANISM(S): Staphylococcus aureus 
2025-04-22 | PXD056653 | Pride
Staphylococcus aureus  virulence  proteases  peptidoglycan hydrolase  cell lysis 
ProteomicsComparative exoproteome and virulence analysis of different clusters of Staphylococcus aureus with the Sequence Type ST398
Livestock-associated (LA) methicillin-resistant Staphylococcus aureus (MRSA) and strains of sequence type 398 (ST398), which first became known for its widespread colonization of pigs but are now also rapidly emerging in the number of human colonization and infections. The ability of broad host adap...
ORGANISM(S): Staphylococcus aureus 
2020-08-05 | PXD013951 | Pride
Virulence Methicillin-resistant staphylococcus aureus (mrsa) Mobile genetic elements (mge) Extracellular proteome Label-free quantitative mass spectrometry 
ProteomicsConnections between exoproteome heterogeneity and virulence in the oral pathogen Aggregatibacter actinomycetemcomitans
Aggregatibacter actinomycetemcomitans (Aa) is a Gram-negative bacterial pathogen associated with severe periodontitis and non-oral diseases. Clinical isolates of Aa display a rough (R) colony phenotype with strong adherent properties. Upon prolonged culturing, non-adherent strains with a smooth (S) ...
ORGANISM(S): Aggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans) (Haemophilus actinomycetemcomitans) 
2022-06-01 | PXD028940 | Pride
Aggregatibacter actinomycetemcomitans Virulence Exoproteome Serotype 
ProteomicsIron regulation in Clostridioides difficile
The response to iron limitation of several bacteria is regulated by the ferric uptake regulator (Fur). The Fur-regulated transcriptional, translational and metabolic networks of the Gram-positive, pathogen Clostridioides difficile were investigated by a combined RNA sequencing, proteomic, metabolomi...
ORGANISM(S): Clostridioides difficile 050-P50-2011 
2019-01-11 | PXD011161 | Pride
Metabolism Fur Iron transport. cell wall Iron regulation Polyamine 
ProteomicsThe leader peptide peTrpL forms antibiotic-containing ribonucleoprotein complexes for posttranscriptional regulation of multiresistance genes
Bacterial ribosome-dependent attenuators are widespread posttranscriptional regulators. They harbour small upstream ORFs (uORFs) encoding leader peptides, for which no functions in trans are known yet. In the soil-dwelling plant symbiont Sinorhizobium meliloti, the tryptophan biosynthesis gene trpE(...
ORGANISM(S): Rhizobium meliloti (Ensifer meliloti) (Sinorhizobium meliloti) 
2020-05-19 | PXD018342 | Pride
Small proteins Posttranscriptional regulation Attenuator Multiresistance Sinorhizobium meliloti Quantification 
ProteomicsSpectral library based analysis of arginine phosphorylations in Staphylococcus aureus
Reversible protein phosphorylation is one of the major mechanisms in the regulation of protein expression and protein activity, controlling physiological functions of the important human pathogen Staphylococcus aureus. Phosphorylations at serine, threonine and tyrosine are known to influence for exa...
ORGANISM(S): Staphylococcus aureus 
2017-12-06 | PXD007167 | Pride
Staphylococcus aureus Gel-free proteomics Arginine phosphorylation Phosphopeptide enrichment Spectral library 
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