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ProteomicsStress enhances secretory autophagy increasing extracellular Bdnf maturation
Stress response is a fundamental mechanism to maintain a healthy homeostasis and its disruption is implicated in several psychiatric disorders. Autophagy is one of the mechanisms regulating homeostasis, and it is known to be activated by cellular stressors such as starvation. In a previous study, w...
ORGANISM(S): Homo sapiens (Human) 
2021-08-25 | PXD017328 | Pride
Human Lc-msms Interactome 
ProteomicsExtracellular vesicles are crucial mediators in orchestrating brain development and disease
Extracellular vesicles have been the center of many studies focusing on neuron-to-neuron communication while the role of EVs in progenitor-to-neuron and -astrocyte communication occurring during brain development has not been systematically investigated. In this project, we focus on the physiologica...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD028438 | Pride
Cerebral organoids Neurodevelopmental disease Lc-msms Brain development Extracellular vesicles Cstb 
ProteomicsNeuronal Hyperactivity in Neurons Derived from Individuals with Grey Matter Heterotopia
Periventricular heterotopia (PH), the most common form of grey matter heterotopia, represents a cortical malformation that is often associated with developmental delay and drug-resistant seizures1,2. The detailed neurophysiological underpinnings of PH symptoms in humans remain, however, elusive. Hum...
ORGANISM(S): Homo sapiens (Human) 
2025-01-13 | PXD038760 | Pride
Human Neuronal hyperactivity. fat4 Qe plus Periventricular heterotopia O cerebral rganoids Dchs1 
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